Wenbin Guo1,2,3,4,5, Feng Liu6, Jindong Chen1,2,3,4,5, Renrong Wu1,2,3,4,5, Lehua Li1,2,3,4,5, Zhikun Zhang7, Huafu Chen6, Jingping Zhao1,2,3,4,5. 1. 1 Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, China. 2. 2 Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, China. 3. 3 National Clinical Research Center on Mental Disorders, Changsha, China. 4. 4 National Technology Institute on Mental Disorders, Changsha, China. 5. 5 Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China. 6. 6 Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. 7. 7 Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Abstract
BACKGROUND: Previous studies on brain function alterations associated with antipsychotic treatment for schizophrenia have produced conflicting results because they used short treatment periods and different designs. METHODS: Resting-state functional magnetic resonance imaging scans were obtained from 17 drug-free patients with recurrent schizophrenia and 24 healthy controls. The patients were treated with olanzapine for 6 months and were scanned at three time points (baseline, 6 weeks of treatment and 6 months of treatment). Network homogeneity was used to analyze the imaging data to examine default-mode network homogeneity alterations associated with antipsychotic treatment. RESULTS: Compared with the controls, the patients at baseline showed increased network homogeneity in the bilateral precuneus and decreased network homogeneity in the bilateral middle temporal gyrus. Network homogeneity values in the bilateral precuneus decreased, and network homogeneity values in the left superior medial prefrontal cortex and the right middle temporal gyrus increased in patients administered olanzapine as antipsychotic treatment. By contrast, network homogeneity values in the left middle temporal gyrus remained unchanged in patients after treatment. CONCLUSION: This study provides evidence that antipsychotic treatment with olanzapine modulates the default-mode network homogeneity in schizophrenia. These findings contribute to the understanding of antipsychotic treatment effects on brain functions.
BACKGROUND: Previous studies on brain function alterations associated with antipsychotic treatment for schizophrenia have produced conflicting results because they used short treatment periods and different designs. METHODS: Resting-state functional magnetic resonance imaging scans were obtained from 17 drug-free patients with recurrent schizophrenia and 24 healthy controls. The patients were treated with olanzapine for 6 months and were scanned at three time points (baseline, 6 weeks of treatment and 6 months of treatment). Network homogeneity was used to analyze the imaging data to examine default-mode network homogeneity alterations associated with antipsychotic treatment. RESULTS: Compared with the controls, the patients at baseline showed increased network homogeneity in the bilateral precuneus and decreased network homogeneity in the bilateral middle temporal gyrus. Network homogeneity values in the bilateral precuneus decreased, and network homogeneity values in the left superior medial prefrontal cortex and the right middle temporal gyrus increased in patients administered olanzapine as antipsychotic treatment. By contrast, network homogeneity values in the left middle temporal gyrus remained unchanged in patients after treatment. CONCLUSION: This study provides evidence that antipsychotic treatment with olanzapine modulates the default-mode network homogeneity in schizophrenia. These findings contribute to the understanding of antipsychotic treatment effects on brain functions.
Authors: Paul Cernasov; Erin C Walsh; Jessica L Kinard; Lisalynn Kelley; Rachel Phillips; Angela Pisoni; Tory A Eisenlohr-Moul; Macey Arnold; Sarah C Lowery; Marcy Ammirato; Kinh Truong; Gabriela A Nagy; Jason A Oliver; Kevin Haworth; Moria Smoski; Gabriel S Dichter Journal: J Affect Disord Date: 2021-05-28 Impact factor: 6.533