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Literature DB >> 28605637

Hepatitis B surface antigen on subviral particles reduces the neutralizing effect of anti-HBs antibodies on hepatitis B viral particles in vitro.

Gustaf E Rydell¹, Kasthuri Prakash², Heléne Norder³, Magnus Lindh⁴.

Abstract

During hepatitis B virus (HBV) infections subviral particles (SVP) consisting mainly of hepatitis B surface antigen are present at much higher concentration than viral particles (VP) in serum. To investigate reasons for this excess of SVP production, SVP and VP were fractionated on a Nycodenz gradient and analyzed for HBV infection of HepG2-NTCP cells with and without anti-HBs antibodies. Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SVP had little effect on viral entry, supporting the assumption that SVP serve as decoy facilitating cell-to-cell spread of HBV in the presence of neutralizing antibodies.

Entities: Disease Species

Keywords: Attachment; Dane particles; HBV; HBsAg; Neutralisation

Mesh：

Substances：

Year: 2017 PMID： 28605637 DOI： 10.1016/j.virol.2017.05.017

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

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Cited

20 in total

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4. PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection.

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Hepatitis B surface antigen on subviral particles reduces the neutralizing effect of anti-HBs antibodies on hepatitis B viral particles in vitro.

1. N-Linked Glycosylation Is Not Essential for Sodium Taurocholate Cotransporting Polypeptide To Mediate Hepatitis B Virus Infection In Vitro.

2. Immune Evasion Strategies Used by Zika Virus to Infect the Fetal Eye and Brain.

Review 3. Antigen Load and T Cell Function: A Challenging Interaction in HBV Infection.

4. PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection.

Review 5. Current Progress of Virus-mimicking Nanocarriers for Drug Delivery.

6. Circulating and intrahepatic antiviral B cells are defective in hepatitis B.

Review 7. Evolutionary and Structural Overview of Human Picornavirus Capsid Antibody Evasion.

8. High serum levels of pregenomic RNA reflect frequently failing reverse transcription in hepatitis B virus particles.

Review 9. Hepatitis B Virus (HBV) Subviral Particles as Protective Vaccines and Vaccine Platforms.

10. Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies.