Literature DB >> 28605228

Sexual Assault and HIV Postexposure Prophylaxis at an Urban African Hospital.

Eric Munene Muriuki1,2, Joshua Kimani2,3, Zipporah Machuki2, James Kiarie1,4,5,6, Alison C Roxby4,7.   

Abstract

Antiretroviral postexposure prophylaxis (PEP) may be underutilized in sexual assault cases in Kenya. This study evaluated the characteristics of survivors of sexual violence attending the Gender-Based Violence Recovery Center (GBVRC) at the Kenyatta National Hospital and reviewed the uptake, adherence, and outcomes of those initiated on PEP. In a retrospective cohort, data from charts of the assaulted seen at the GBVRC from 2009 to 2012 were abstracted. Data were collected describing sociodemographic characteristics, nature of sexual assault, HIV serostatus, and aspects of the PEP care cascade. Characteristics of participants who received PEP were compared with those who did not receive PEP. We enrolled 385 assaulted persons; 331 (86%) were female; the median age of the assaulted persons was 21 (interquartile range 14-28) years; and 61 (15.8%) were children aged 10 years and younger. Of 379 assaults with descriptions, 330 (85.7%) were vaginal assaults and 40 (10.3%) were penile-anal assaults. Most perpetrators were unknown to the assaulted 220 of 384 (57.3%). All assaulted persons were offered HIV testing and 359 (93%) accepted testing; 346 (96.4%) of 359 assaulted persons tested HIV negative. In total, 207 (53.8%) of 385 sexual assault survivors initiated PEP. Only 70 (34%) completed 28 days of PEP, and only 21 (10.1%) returned for repeat HIV test at 3 months. In conclusion, PEP was only initiated in 54% of sexual assault cases. The care cascade showed that late presentation and poor adherence were the greatest gaps in PEP provision. Earlier presentation for PEP should be promoted among sexual assault in areas of high HIV prevalence.

Entities:  

Keywords:  GBVRC; HIV; antiretroviral; postexposure prophylaxis; rape; sexual assault

Mesh:

Substances:

Year:  2017        PMID: 28605228      PMCID: PMC5488309          DOI: 10.1089/apc.2016.0274

Source DB:  PubMed          Journal:  AIDS Patient Care STDS        ISSN: 1087-2914            Impact factor:   5.078


  14 in total

Review 1.  Sexual assault injuries and increased risk of HIV transmission.

Authors:  Jessica E Draughon
Journal:  Adv Emerg Nurs J       Date:  2012 Jan-Mar

Review 2.  Resistance to anti-human immunodeficiency virus therapeutic agents.

Authors:  E A Emini
Journal:  Adv Exp Med Biol       Date:  1995       Impact factor: 2.622

Review 3.  Adherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysis.

Authors:  Liza Chacko; Nathan Ford; Mariam Sbaiti; Ruby Siddiqui
Journal:  Sex Transm Infect       Date:  2012-02-13       Impact factor: 3.519

4.  Prevalence and incidence of HIV infection, trends, and risk factors among persons aged 15-64 years in Kenya: results from a nationally representative study.

Authors:  Davies O Kimanga; Samuel Ogola; Mamo Umuro; Anne Ng'ang'a; Lucy Kimondo; Patrick Murithi; James Muttunga; Wanjiru Waruiru; Ibrahim Mohammed; Shahnaaz Sharrif; Kevin M De Cock; Andrea A Kim
Journal:  J Acquir Immune Defic Syndr       Date:  2014-05-01       Impact factor: 3.731

5.  Postexposure prophylaxis after nonoccupational HIV exposure: clinical, ethical, and policy considerations.

Authors:  P Lurie; S Miller; F Hecht; M Chesney; B Lo
Journal:  JAMA       Date:  1998-11-25       Impact factor: 56.272

Review 6.  Rape and HIV post-exposure prophylaxis: addressing the dual epidemics in South Africa.

Authors:  Julia C Kim; Lorna J Martin; Lynette Denny
Journal:  Reprod Health Matters       Date:  2003-11

7.  The structure and outcomes of a HIV postexposure prophylaxis program in a high HIV prevalence setup in western Kenya.

Authors:  Abraham M Siika; Winston M Nyandiko; Ann Mwangi; Michael Waxman; John E Sidle; Sylvester N Kimaiyo; Kara Wools-Kaloustian
Journal:  J Acquir Immune Defic Syndr       Date:  2009-05-01       Impact factor: 3.731

8.  Formulating the Future Research Agenda for Postexposure Prophylaxis for HIV: Methodological Challenges and Potential Approaches.

Authors:  Nandi Siegfried; Rachel L Beanland; Nathan Ford; Kenneth H Mayer
Journal:  Clin Infect Dis       Date:  2015-06-01       Impact factor: 9.079

9.  Is violence associated with increased risk behavior among MSM? Evidence from a population-based survey conducted across nine cities in Central America.

Authors:  Jennifer Wheeler; Katherine Anfinson; Dennis Valvert; Susana Lungo
Journal:  Glob Health Action       Date:  2014-10-23       Impact factor: 2.640

Review 10.  Adherence to HIV postexposure prophylaxis: a systematic review and meta-analysis.

Authors:  Nathan Ford; Cadi Irvine; Zara Shubber; Rachel Baggaley; Rachel Beanland; Marco Vitoria; Meg Doherty; Edward J Mills; Alexandra Calmy
Journal:  AIDS       Date:  2014-11-28       Impact factor: 4.177

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  1 in total

1.  HIV Non-Occupational Post Exposure Prophylaxis in Nigeria: A Systematic Review of Research Evidence and Practice.

Authors:  Sorochi H Iloanusi; Osaro O Mgbere; Susan M Abughosh; Ekere J Essien
Journal:  Int J MCH AIDS       Date:  2019-11-18
  1 in total

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