Seyedtaghi Mirmohammadi1, Yosef Moghaddasi2, Jamshid Yazdani3, Razyeh Yousefinejad4, Yahya Esfandyari5, Mohsen Gorgani6, Manijeh Habibpour7. 1. Mazandaran University of Medical Sciences, Sari, Iran (Molecular and Cellular Biology Research Center). seyedtaghim@gmail.com. 2. Mazandaran University of Medical Sciences, Sari, Iran (Molecular and Cellular Biology Research Center). ymoghaddasi14@gmail.com. 3. Mazandaran University of Medical Sciences, Sari, Iran (Faculty of Health Sciences, Department of Biostatistics). jamshid_1380@yahoo.com. 4. Mazandaran University of Medical Sciences, Sari, Iran (Faculty of Health Sciences, Department of Occupational Health). mirtaghim@yahoo.com. 5. Mazandaran University of Medical Sciences, Sari, Iran (Faculty of Health Sciences, Department of Environmental Health). yesfandyari48@yahoo.com. 6. Mazandaran University of Medical Sciences, Sari, Iran (Faculty of Health Sciences, Department of Occupational Health). gorgani_mo@yahoo.com. 7. Mazandaran University of Medical Sciences, Sari, Iran (Faculty of Pharmacy).
Abstract
BACKGROUND: Manganese (Mn) used as raw material for melting process in the ferrous foundry is considered as hazardous neurotoxic substance because it accumulates in the central nervous system and may cause neurological disorders. The furnace-men and melting department workers are potentially exposed to manganese particles or fume in the workplace. The objective of the research has been to investigate the sources and levels of manganese exposure in the foundry by correlation of blood-manganese (B-Mn) and air-manganese (air-Mn) measurement. MATERIAL AND METHODS: Air-Mn and Mn of blood serum were measured involving workers who worked in a big-sized foundry during 1 year. The standard method of the Occupational Safety and Health Administration (OSHA) ID-121 was used for air and blood assessment and atomic absorption spectroscopy (AAS) was carried out for air and blood sample analysis. RESULTS: The air sampling results have revealed that there is a high exposure to manganese (4.5 mg/m<sup>3</sup>) in the workplace as compared to the National Institute for Occupational Safety and Health's (NIOSH) time weighted average (the reference time-weighted average (TWA) = 1 mg/m<sup>3</sup>). The average blood serum Mn concentration was 2.745 μg/l for subjects working for shorter than 3 months and 274.85 μg/l for subjects working 3-12 months. CONCLUSIONS: Against the research hypothesis there was no correlation between the air-Mn concentration and the B-Mn (serum) level of manganese in the serum of the exposed subjects. It may be due to short time of air sampling of manganese airborne particles, and a real-time monitoring of airborne manganese particles is suggested for any future study. Med Pr 2017;68(4):449-458. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
BACKGROUND:Manganese (Mn) used as raw material for melting process in the ferrous foundry is considered as hazardous neurotoxic substance because it accumulates in the central nervous system and may cause neurological disorders. The furnace-men and melting department workers are potentially exposed to manganese particles or fume in the workplace. The objective of the research has been to investigate the sources and levels of manganese exposure in the foundry by correlation of blood-manganese (B-Mn) and air-manganese (air-Mn) measurement. MATERIAL AND METHODS: Air-Mn and Mn of blood serum were measured involving workers who worked in a big-sized foundry during 1 year. The standard method of the Occupational Safety and Health Administration (OSHA) ID-121 was used for air and blood assessment and atomic absorption spectroscopy (AAS) was carried out for air and blood sample analysis. RESULTS: The air sampling results have revealed that there is a high exposure to manganese (4.5 mg/m<sup>3</sup>) in the workplace as compared to the National Institute for Occupational Safety and Health's (NIOSH) time weighted average (the reference time-weighted average (TWA) = 1 mg/m<sup>3</sup>). The average blood serum Mn concentration was 2.745 μg/l for subjects working for shorter than 3 months and 274.85 μg/l for subjects working 3-12 months. CONCLUSIONS: Against the research hypothesis there was no correlation between the air-Mn concentration and the B-Mn (serum) level of manganese in the serum of the exposed subjects. It may be due to short time of air sampling of manganese airborne particles, and a real-time monitoring of airborne manganese particles is suggested for any future study. Med Pr 2017;68(4):449-458. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
Entities:
Keywords:
air and blood assessment; atomic absorption spectroscopy; blood assessment; foundry; manganese airborne particle; workers
Authors: Danelle Rolle-McFarland; Yingzi Liu; Farshad Mostafaei; S Elizabeth Zauber; Yuanzhong Zhou; Yan Li; Quiyan Fan; Wei Zheng; Linda H Nie; Ellen M Wells Journal: Neurotoxicology Date: 2021-12-10 Impact factor: 4.294
Authors: Chao-Yan Ou; Yong-Hua He; Yi Sun; Lin Yang; Wen-Xiang Shi; Shao-Jun Li Journal: Int J Environ Res Public Health Date: 2019-06-18 Impact factor: 3.390