OBJECTIVES: To evaluate the effectiveness of the measles-mumps-rubella (MMR) vaccine in reducing hospitalizations for infectious disease, targeted and not targeted, as well as from respiratory diseases in children in Rome. METHODS: The cohort was recomposed through record linkage of 2 archives (vaccination register and hospital discharge records. RESULTS: The analysis included 11,004 children. 20.9% did not receive the MMR vaccination, 49% and 30.1% received one and 2 doses. There were no hospitalizations for rubella, 2 for mumps, and 12 for measles. The vaccine was highly protective against measles and mumps hospitalizations (HR = 0.10; 95% CI: 0.03.0.34). Regarding all infectious diseases there were 414 hospitalizations, and the vaccine was protective (HR = 0.29; 95% CI: 0.25 to 0.34). Concerning respiratory diseases, there were 809 admissions (7.4%), and the vaccine was highly protective (HR: 0.18; 95% CI: 0.07 to 0.48). CONCLUSIONS: MMR vaccination is effective for the primary prevention of target and not targeted infectious diseases and may also limit hospitalizations for respiratory diseases.
OBJECTIVES: To evaluate the effectiveness of the measles-mumps-rubella (MMR) vaccine in reducing hospitalizations for infectious disease, targeted and not targeted, as well as from respiratory diseases in children in Rome. METHODS: The cohort was recomposed through record linkage of 2 archives (vaccination register and hospital discharge records. RESULTS: The analysis included 11,004 children. 20.9% did not receive the MMR vaccination, 49% and 30.1% received one and 2 doses. There were no hospitalizations for rubella, 2 for mumps, and 12 for measles. The vaccine was highly protective against measles and mumps hospitalizations (HR = 0.10; 95% CI: 0.03.0.34). Regarding all infectious diseases there were 414 hospitalizations, and the vaccine was protective (HR = 0.29; 95% CI: 0.25 to 0.34). Concerning respiratory diseases, there were 809 admissions (7.4%), and the vaccine was highly protective (HR: 0.18; 95% CI: 0.07 to 0.48). CONCLUSIONS: MMR vaccination is effective for the primary prevention of target and not targeted infectious diseases and may also limit hospitalizations for respiratory diseases.
Authors: Maria Kakoulidou; Hanna Ingelman-Sundberg; Elin Johansson; Alberto Cagigi; Salah Eldin Farouk; Anna Nilsson; Kari Johansen Journal: Vaccine Date: 2012-11-19 Impact factor: 3.641
Authors: Vincenzo Restivo; Giuseppe Napoli; Maria Grazia Laura Marsala; Valentina Bonanno; Valentina Sciuto; Emanuele Amodio; Giuseppe Calamusa; Francesco Vitale; Alberto Firenze Journal: Hum Vaccin Immunother Date: 2014-11-01 Impact factor: 3.452
Authors: Fangjun Zhou; Abigail Shefer; Jay Wenger; Mark Messonnier; Li Yan Wang; Adriana Lopez; Matthew Moore; Trudy V Murphy; Margaret Cortese; Lance Rodewald Journal: Pediatrics Date: 2014-03-03 Impact factor: 7.124
Authors: Adam Edvin Roth; Christine Stabell Benn; Henrik Ravn; Amabelia Rodrigues; Ida Maria Lisse; Maria Yazdanbakhsh; Hilton Whittle; Peter Aaby Journal: BMJ Date: 2010-03-15