Ivonne P M Derks1,2, Desana Kocevska1,2, Vincent W V Jaddoe2,3,4, Oscar H Franco3, Melissa Wake5,6,7, Henning Tiemeier1,3,8, Pauline W Jansen1,6,9. 1. 1 Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center , Rotterdam, The Netherlands . 2. 2 The Generation R Study Group, Erasmus MC-University Medical Center , Rotterdam, The Netherlands . 3. 3 Department of Epidemiology, Erasmus MC-University Medical Center , Rotterdam, The Netherlands . 4. 4 Department of Pediatrics, Erasmus MC-University Medical Center , Rotterdam, The Netherlands . 5. 5 Department of Paediatrics and the Liggins Institute, The University of Auckland , Auckland, New Zealand . 6. 6 Centre for Community Child Health, Murdoch Children's Research Institute , Melbourne, Australia . 7. 7 Department of Pediatrics, The University of Melbourne , Melbourne, Australia . 8. 8 Department of Psychiatry, Erasmus MC-University Medical Center , Rotterdam, The Netherlands . 9. 9 Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam , Rotterdam, The Netherlands .
Abstract
BACKGROUND: A short sleep duration is associated with a higher obesity risk from midchildhood onward. However, whether sleep duration in early childhood is associated with body composition and cardiometabolic health remains unclear. This study aims to examine the prospective association of sleep duration in infancy and early childhood with body composition and cardiometabolic health at 6 years of age. METHODS: Data were available for 5161 children from a population-based cohort in the Netherlands. Sleep duration was assessed at ages 2, 6, 24, and 36 months by parental reports. When children were 6 years old, measures of body composition (iDXA), blood pressure, insulin, and lipid levels were collected. Longitudinal associations among sleep duration, body composition, and cardiometabolic health were studied with multivariable linear regression analyses. In addition, potential bidirectional associations between sleep duration and BMI were studied by using cross-lagged modeling. RESULTS: Shorter sleep duration at 2 months predicted higher BMI and fat mass in 6-year-old children, accounting for confounders and BMI at 2 months (e.g., for BMI, per hour sleep, B = -0.018, 95% CI = -0.026; -0.009). No temporal relationships among sleep duration at other ages, later body composition, and cardiometabolic outcomes were found. The cross-lagged model indicated a bidirectional association between sleep duration and BMI in early life (2 to 6 months of age). CONCLUSIONS: Shorter sleep duration at 2 months, but not at later ages, predicted poorer body composition 6 years later. We found no clear evidence for an effect of sleep duration in early life on cardiometabolic health.
BACKGROUND: A short sleep duration is associated with a higher obesity risk from midchildhood onward. However, whether sleep duration in early childhood is associated with body composition and cardiometabolic health remains unclear. This study aims to examine the prospective association of sleep duration in infancy and early childhood with body composition and cardiometabolic health at 6 years of age. METHODS: Data were available for 5161 children from a population-based cohort in the Netherlands. Sleep duration was assessed at ages 2, 6, 24, and 36 months by parental reports. When children were 6 years old, measures of body composition (iDXA), blood pressure, insulin, and lipid levels were collected. Longitudinal associations among sleep duration, body composition, and cardiometabolic health were studied with multivariable linear regression analyses. In addition, potential bidirectional associations between sleep duration and BMI were studied by using cross-lagged modeling. RESULTS: Shorter sleep duration at 2 months predicted higher BMI and fat mass in 6-year-old children, accounting for confounders and BMI at 2 months (e.g., for BMI, per hour sleep, B = -0.018, 95% CI = -0.026; -0.009). No temporal relationships among sleep duration at other ages, later body composition, and cardiometabolic outcomes were found. The cross-lagged model indicated a bidirectional association between sleep duration and BMI in early life (2 to 6 months of age). CONCLUSIONS: Shorter sleep duration at 2 months, but not at later ages, predicted poorer body composition 6 years later. We found no clear evidence for an effect of sleep duration in early life on cardiometabolic health.
Authors: Jiaxiao Yu; Huili Jin; Li Wen; Wenjin Zhang; Richard Saffery; Chao Tong; Hongbo Qi; Mark D Kilby; Philip N Baker Journal: J Clin Sleep Med Date: 2021-11-01 Impact factor: 4.062
Authors: Sofía I Mercado-Gonzales; Antonella N Carpio-Rodríguez; Rodrigo M Carrillo-Larco; Antonio Bernabé-Ortiz Journal: Child Obes Date: 2019-02-27 Impact factor: 2.867
Authors: Monica R Ordway; Eileen M Condon; Bridget Basile Ibrahim; Emily A Abel; Melissa C Funaro; Janene Batten; Lois S Sadler; Nancy S Redeker Journal: Sleep Med Rev Date: 2021-05-01 Impact factor: 11.401