Literature DB >> 28603721

Helping prometheus: liver protection in acute hemorrhagic shock.

Nils T Veith1, Tina Histing1, Michael D Menger2, Tim Pohlemann1, Thomas Tschernig3.   

Abstract

Acute hemorrhagic hypovolemic shock is caused by a significant high blood loss and leads to hemodynamic instability. The decrease in intravascular volume results in cellular hypoxia and finally in damage to organs such as the liver and the kidney. The liver plays a decisive role in the development or prevention of multiple organ failure after hemorrhagic shock. Despite the large number of experimental studies, the knowledge of pathophysiological mechanisms in the liver after hemorrhagic shock is incomplete. The aim of this mini review was to provide an overview of the pathophysiological changes in liver function after acute hemorrhagic shock and to address treatment options to improve liver perfusion.

Entities:  

Keywords:  Adrenomedullin; experimental treatment; hemorrhagic shock; intravital microscopy; liver perfusion

Year:  2017        PMID: 28603721      PMCID: PMC5451618          DOI: 10.21037/atm.2017.03.109

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN: 2305-5839


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  8 in total

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