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Literature DB >> 28601936

Acute kidney injury: emerging pharmacotherapies in current clinical trials.

Stefanie Woolridge Benoit¹, Prasad Devarajan².

Abstract

Acute kidney injury (AKI) is a significant source of morbidity and mortality in pediatric patients, affecting more than one quarter of critically ill children. Despite significant need, there are no targeted therapies to reliably prevent or treat AKI. Recent advances in our understanding of renal injury and repair signaling pathways have enabled the development of several targeted pharmaceuticals. Here we review emerging pharmacotherapies for AKI that are currently in clinical trials. Categorized by their general mechanism of action, the therapies discussed include anti-inflammatory agents (recAP, AB103, ABT-719), antioxidants (iron chelators, heme arginate), vasodilators (levosimendan), apoptosis inhibitors (QPI-1002), and repair agents (THR-184, BB-3, mesenchymal stem cells).

Entities: Chemical Disease Gene Species

Keywords: Acute kidney injury; Acute renal failure; Clinical trials; Pediatric; Therapeutics

Mesh：

Substances：

Year: 2017 PMID： 28601936 PMCID： PMC5723563 DOI： 10.1007/s00467-017-3695-3

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

55 in total

1. Renal Hemodynamics in AKI: In Search of New Treatment Targets.

Authors: Martin Matejovic; Can Ince; Lakhmir S Chawla; Roland Blantz; Bruce A Molitoris; Mitchell H Rosner; Mark D Okusa; John A Kellum; Claudio Ronco
Journal: J Am Soc Nephrol Date: 2015-10-28 Impact factor: 10.121

2. Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES.

Authors: Rujun Gong; Abdalla Rifai; Evelyn M Tolbert; Purba Biswas; Jason N Centracchio; Lance D Dworkin
Journal: J Am Soc Nephrol Date: 2004-11 Impact factor: 10.121

3. Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001.

Authors: Shirley Hui-Stickle; Eileen D Brewer; Stuart L Goldstein
Journal: Am J Kidney Dis Date: 2005-01 Impact factor: 8.860

4. A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial.

Authors: Eileen M Bulger; Ronald V Maier; Jason Sperry; Manjari Joshi; Sharon Henry; Frederick A Moore; Lyle L Moldawer; Demetrios Demetriades; Peep Talving; Martin Schreiber; Bruce Ham; Mitchell Cohen; Steven Opal; Irit Segalovich; Greg Maislin; Raymond Kaempfer; Anat Shirvan
Journal: JAMA Surg Date: 2014-06 Impact factor: 14.766

5. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

Authors: S Vukicevic; V Basic; D Rogic; N Basic; M S Shih; A Shepard; D Jin; B Dattatreyamurty; W Jones; H Dorai; S Ryan; D Griffiths; J Maliakal; M Jelic; M Pastorcic; A Stavljenic; T K Sampath
Journal: J Clin Invest Date: 1998-07-01 Impact factor: 14.808

Review 6. The path to chronic kidney disease following acute kidney injury: a neonatal perspective.

Authors: Swasti Chaturvedi; Kar Hui Ng; Cherry Mammen
Journal: Pediatr Nephrol Date: 2016-01-25 Impact factor: 3.714

7. Levosimendan for Prevention of Acute Kidney Injury After Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.

Authors: Chenghui Zhou; Junsong Gong; Dong Chen; Weipeng Wang; Mingzheng Liu; Bin Liu
Journal: Am J Kidney Dis Date: 2015-10-27 Impact factor: 8.860

8. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial.

Authors: Peter Pickkers; Suzanne Heemskerk; Jeroen Schouten; Pierre-François Laterre; Jean-Louis Vincent; Albertus Beishuizen; Philippe G Jorens; Herbert Spapen; Michael Bulitta; Wilbert H M Peters; Johannes G van der Hoeven
Journal: Crit Care Date: 2012-01-23 Impact factor: 9.097

Review 9. CD28: direct and critical receptor for superantigen toxins.

Authors: Raymond Kaempfer; Gila Arad; Revital Levy; Dalia Hillman; Iris Nasie; Ziv Rotfogel
Journal: Toxins (Basel) Date: 2013-09-09 Impact factor: 4.546

Review 10. Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence.

Authors: Anna Julie Peired; Alessandro Sisti; Paola Romagnani
Journal: Stem Cells Int Date: 2016-09-19 Impact factor: 5.443

13 in total

1. Paediatric acute kidney injury: can we match therapy with resources around the world?

Authors: Akash Deep; Jordan M Symons; Mignon McCulloch
Journal: Intensive Care Med Date: 2018-04-16 Impact factor: 17.440

2. Urine Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 to Detect Pediatric Cisplatin-Associated Acute Kidney Injury.

Authors: Kelly R McMahon; Hayton Chui; Shahrad Rod Rassekh; Kirk R Schultz; Tom D Blydt-Hansen; Cherry Mammen; Maury Pinsk; Geoffrey D E Cuvelier; Bruce C Carleton; Ross T Tsuyuki; Colin J D Ross; Prasad Devarajan; Louis Huynh; Mariya Yordanova; Frédérik Crépeau-Hubert; Stella Wang; Vedran Cockovski; Ana Palijan; Michael Zappitelli
Journal: Kidney360 Date: 2021-11-03

Review 3. Advances in pediatric acute kidney injury.

Authors: Rupesh Raina; Ronith Chakraborty; Abhishek Tibrewal; Sidharth K Sethi; Timothy Bunchman
Journal: Pediatr Res Date: 2021-03-17 Impact factor: 3.756

Review 4. Minimizing Ischemia Reperfusion Injury in Xenotransplantation.

Authors: Parth M Patel; Margaret R Connolly; Taylor M Coe; Anthony Calhoun; Franziska Pollok; James F Markmann; Lars Burdorf; Agnes Azimzadeh; Joren C Madsen; Richard N Pierson
Journal: Front Immunol Date: 2021-09-09 Impact factor: 7.561

5. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.

Authors: Maria Agustina Battistone; Alexandra C Mendelsohn; Raul German Spallanzani; Andrew S Allegretti; Rachel N Liberman; Juliana Sesma; Sahir Kalim; Susan M Wall; Joseph V Bonventre; Eduardo R Lazarowski; Dennis Brown; Sylvie Breton
Journal: J Clin Invest Date: 2020-07-01 Impact factor: 14.808

6. Sustained local inhibition of thrombin preserves renal microarchitecture and function after onset of acute kidney injury.

Authors: Ian Vargas; Daniel J Stephenson; Margaret Baldwin; Joseph P Gaut; Charles E Chalfant; Hua Pan; Samuel A Wickline
Journal: Nanomedicine Date: 2021-07-23 Impact factor: 5.307