Hans Pottel1, Laurence Dubourg2, Elke Schaeffner3, Bjørn Odvar Eriksen4, Toralf Melsom4, Edmund J Lamb5, Andrew D Rule6, Stephen T Turner6, Richard J Glassock7, Vandréa De Souza8, Luciano Selistre9, Karolien Goffin10, Steven Pauwels11, Christophe Mariat12, Martin Flamant13, Sebastjan Bevc14, Pierre Delanaye15, Natalie Ebert3. 1. Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium. Electronic address: Hans.Pottel@kuleuven-kulak.be. 2. Exploration Fonctionnelle Rénale, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France. 3. Charité University Hospital, Institute of Public Health, Berlin, Germany. 4. Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway. 5. Clinical Biochemistry, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, United Kingdom. 6. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA. 7. Geffen School of Medicine at UCLA, Laguna Niguel, California, USA. 8. Universidade de Caxias do Sul, Programa de Pós Graduação em Ciências da Saúde, Brazil. 9. Universidade de Caxias do Sul, Programa de Pós Graduação em Ciências da Saúde, Brazil; Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. 10. Department of Nuclear Medicine & Molecular Imaging, University Hospital Leuven, Leuven, Belgium. 11. Department of Cardiovascular Sciences, Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium. 12. Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, France. 13. Department of Renal Physiology, Hôpital Bichat, AP-HP and Paris Diderot University, Paris, France. 14. University Medical Centre Maribor, Clinic for Internal Medicine, Department of Nephrology, Maribor, Slovenia. 15. Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.
Abstract
BACKGROUND: Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between 'rescaled' levels of these renal biomarkers (with reference interval of [0.67-1.33]) and measured GFR (mGFR). METHODS: We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC. We calculated sensitivity and specificity of the rescaled biomarkers to identify kidney disease, with reference to a fixed (60mL/min/1.73m2) as well as an age-dependent threshold for mGFR. RESULTS: The upper reference limit of 1.33 for rescaled renal biomarkers is closely related to the age-dependent threshold for defining kidney status by mGFR with sensitivity and specificity for the rescaled biomarkers close to 90% for all ages. If the fixed threshold of 60mL/min/1.73m2 for mGFR is used, then lower specificity in children and sensitivity in older adults are observed. CONCLUSIONS: Impaired kidney function can be diagnosed by rescaled renal biomarkers instead of eGFR-equations using the fixed threshold of 1.33 for all ages, consistent with an age-dependent threshold of mGFR.
BACKGROUND: Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between 'rescaled' levels of these renal biomarkers (with reference interval of [0.67-1.33]) and measured GFR (mGFR). METHODS: We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC. We calculated sensitivity and specificity of the rescaled biomarkers to identify kidney disease, with reference to a fixed (60mL/min/1.73m2) as well as an age-dependent threshold for mGFR. RESULTS: The upper reference limit of 1.33 for rescaled renal biomarkers is closely related to the age-dependent threshold for defining kidney status by mGFR with sensitivity and specificity for the rescaled biomarkers close to 90% for all ages. If the fixed threshold of 60mL/min/1.73m2 for mGFR is used, then lower specificity in children and sensitivity in older adults are observed. CONCLUSIONS: Impaired kidney function can be diagnosed by rescaled renal biomarkers instead of eGFR-equations using the fixed threshold of 1.33 for all ages, consistent with an age-dependent threshold of mGFR.
Authors: Hans Pottel; Laurence Dubourg; Elke Schaeffner; Bjørn Odvar Eriksen; Toralf Melsom; Edmund J Lamb; Andrew D Rule; Stephen T Turner; Richard J Glassock; Vandréa De Souza; Luciano Selistre; Karolien Goffin; Steven Pauwels; Christophe Mariat; Martin Flamant; Sebastjan Bevc; Pierre Delanaye; Natalie Ebert Journal: Data Brief Date: 2017-09-01
Authors: Mirjam E van de Velde; Emil den Bakker; Hester N Blufpand; Gertjan L Kaspers; Floor C H Abbink; Arjenne W A Kors; Abraham J Wilhelm; Richard J Honeywell; Godefridus J Peters; Birgit Stoffel-Wagner; Laurien M Buffart; Arend Bökenkamp Journal: Cancers (Basel) Date: 2021-11-26 Impact factor: 6.639