Jacob P Thyssen1, Peter B Toft2, Anne-Sofie Halling-Overgaard3, Gunnar H Gislason4, Lone Skov3, Alexander Egeberg3. 1. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; National Allergy Research Centre, Gentofte, Denmark. Electronic address: jacob.p.thyssen@regionh.dk. 2. Eye Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 3. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. 4. Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; The Danish Heart Foundation, Copenhagen, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Abstract
BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD. OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD. METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression. RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with "cataract only" in individuals <50 years of age. LIMITATIONS: A limitation of the study is that observational studies cannot establish causality. CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.
BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD. OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD. METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression. RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with "cataract only" in individuals <50 years of age. LIMITATIONS: A limitation of the study is that observational studies cannot establish causality. CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.
Authors: Hyun Sun Jeon; Mira Choi; Seong Jun Byun; Joon Young Hyon; Kyu Hyung Park; Sang Jun Park Journal: JAMA Ophthalmol Date: 2018-08-01 Impact factor: 7.389
Authors: Sunny Park; Jung Hyun Lee; Ji Hyun Park; So Hyang Park; Song Yi Park; Yong Woo Jung; Soo An Choi Journal: Sci Rep Date: 2021-07-12 Impact factor: 4.379
Authors: Jacob P Thyssen; Steffen Heegaard; Lena Ivert; Anita Remitz; Tove Agner; Marjolein De Bruin-Weller; Theis Huldt-Nystrøm; Laura Korhonen; Lina U Ivert; Pekka Leinonen; Johanna Mandelin; Tore Särnhult; Thomas Schopf; Eirik Sundlisæter; Simon F Thomsen; Thrasyvoulos Tzellos; Christian Vestergaard; Laura von Kobyletzki; Maria Bradley Journal: Acta Derm Venereol Date: 2020-09-16 Impact factor: 3.875