| Literature DB >> 28601286 |
E K Mathey1, N Garg2, S B Park2, T Nguyen2, S Baker3, N Yuki4, C Yiannikas5, C S Lin6, J M Spies7, R Ghaoui8, M H Barnett2, S Vucic9, J D Pollard2, M C Kiernan2.
Abstract
Autoantibodies to nodal/paranodal proteins have been reported in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). To determine the frequency of anti-paranodal antibodies in our cohort of CIDP patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA. In CIDP patients, 7% were anti-NF155 IgG4 positive and 7% were anti-CNTN1 IgG4 positive. Positive results were confirmed using cell based assays and indirect immunofluorescence on teased nerve fibres. We did not detect IgG autoantibodies against these nodal/paranodal antigens in MMN patients.Entities:
Keywords: Autoantibody; Chronic inflammatory demyelinating polyneuropathy; Contactin; Gliomedin; Multifocal motor neuropathy; Neurofascin
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Year: 2017 PMID： 28601286 DOI： 10.1016/j.jneuroim.2017.05.002
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478