Literature DB >> 28601135

Novel Algorithms for the Prophylaxis and Management of Alcohol Withdrawal Syndromes-Beyond Benzodiazepines.

José R Maldonado1.   

Abstract

Benzodiazepine (BZDP) agents are the standard for the prophylaxis and treatment of all phases of alcohol withdrawal syndrome. However, BZDPs have their drawbacks: cognitive impairment, significant neurologic and medical side effects. There are data suggesting that the alcohol recidivism rate and abuse potential is higher for BZDPs treated patients, compared to alternatives. Clinical and research data demonstrate the efficacy and safety of various pharmacologic alternatives to benzodiazepines for the prevention and management of AWS. This article examines the available published evidence regarding the use of non-BZDP agents compared with conventional treatment modalities. The author's BZDP-sparing protocol is highlighted.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alcohol withdrawal; Alpha-2 agonists; Anticonvulsant agents; Benzodiazepines; Delirium tremens; Withdrawal prophylaxis

Mesh：

Substances：

Year:  2017        PMID： 28601135     DOI： 10.1016/j.ccc.2017.03.012

Source DB:  PubMed          Journal:  Crit Care Clin        ISSN： 0749-0704            Impact factor:   3.598


  6 in total

1.  Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality.

Authors:  Melissa L Masicampo; Hong Qu Shan; Victoria Xu; Merritt Speagle; Dwayne W Godwin
Journal:  Alcohol Alcohol       Date:  2018-09-01       Impact factor: 2.826

Review 2.  Delirium.

Authors:  Jo Ellen Wilson; Matthew F Mart; Colm Cunningham; Yahya Shehabi; Timothy D Girard; Alasdair M J MacLullich; Arjen J C Slooter; E Wesley Ely
Journal:  Nat Rev Dis Primers       Date:  2020-11-12       Impact factor: 65.038

3.  Outcomes After Implementation of a Benzodiazepine-Sparing Alcohol Withdrawal Order Set in an Integrated Health Care System.

Authors:  Joshua T Smith; Mary Sage; Herb Szeto; Laura C Myers; Yun Lu; Adriana Martinez; Patricia Kipnis; Vincent X Liu
Journal:  JAMA Netw Open       Date:  2022-02-01

4.  The Use of Anticonvulsant Adjuncts to Treat Alcohol Withdrawal Syndrome in Older Adults.

Authors:  Stefanie Montgomery; Karen Dahri; Kaveh Rayani; Jacqueline Kwok; Peter Chan
Journal:  Can Geriatr J       Date:  2022-03-02

Review 5.  Substance use disorders: diagnosis and management for hospitalists.

Authors:  Ahmed K Pasha; Arnab Chowdhury; Sanah Sadiq; Jeremiah Fairbanks; Shirshendu Sinha
Journal:  J Community Hosp Intern Med Perspect       Date:  2020-05-21

6.  Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome: An Official American Thoracic Society Research Statement.

Authors:  Tessa L Steel; Majid Afshar; Scott Edwards; Sarah E Jolley; Christine Timko; Brendan J Clark; Ivor S Douglas; Amy L Dzierba; Hayley B Gershengorn; Nicholas W Gilpin; Dwayne W Godwin; Catherine L Hough; José R Maldonado; Anuj B Mehta; Lewis S Nelson; Mayur B Patel; Darius A Rastegar; Joanna L Stollings; Boris Tabakoff; Judith A Tate; Adrian Wong; Ellen L Burnham
Journal:  Am J Respir Crit Care Med       Date:  2021-10-01       Impact factor: 21.405
  6 in total

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