Chao-Ming Tseng1, Shih-Pei Huang2, Wei-Chih Liao3, Chun-Ju Chiang4, Ya-Wen Yang4, Chi-Yang Chang5, Yao-Chun Hsu6, Hui-Chi Chen7, Han-Sun Chiang8, Jaw-Town Lin9. 1. Division of Gastroenterology and Hepatology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan. 2. Department of Public Health, College of Medicine, Fu-Jen Catholic University, Taiwan. 3. Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 4. National Cancer Registry, Taiwan. 5. Division of Gastroenterology and Hepatology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. 6. Division of Gastroenterology and Hepatology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan; Big Data Research Centre, Fu-Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan. Electronic address: holdenhsu@gmail.com. 7. Big Data Research Centre, Fu-Jen Catholic University, New Taipei City, Taiwan. Electronic address: d90842001@gmail.com. 8. School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. 9. Division of Gastroenterology and Hepatology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan; Big Data Research Centre, Fu-Jen Catholic University, New Taipei City, Taiwan.
Abstract
BACKGROUND: Accumulating data has revealed a rapidly rising incidence of pancreatic cancer in Western countries, but convincing evidence from the East remains sparse. We aimed to quantify how the incidence and mortality rates of pancreatic malignancy changed over time in Taiwan, and to develop future projection for the next decade. METHODS: This nationwide population-based study analyzed the Taiwan National Cancer Registry and the National Cause of Death Registry to calculate the annual incidence and mortality rates of pancreatic malignancy from 1999 to 2012 in this country. The secular trend of the incidence was also examined by data from the National Health Insurance Research Database. RESULTS: A total of 21,986 incident cases of pancreatic cancer and 20,720 related deaths occurred during the study period. The age-standardized incidence rate increased from 3.7 per 100,000 in 1999 to 5.0 per 100,000 in 2012, with a significant rising trend (P<0.01). The increase was nationwide, consistently across subgroups stratified by age, gender, geographic region, and urbanization. Data from the National Health Insurance Research Database corroborated the rise of incident pancreatic cancer. Mortality also increased with time, with the age-standardized rate rising from 3.5 per 100,000 in 1999 to 4.1 per 100,000 in 2012 (P<0.01). In accordance with the incidence, the mortality trend was consistent in all subgroups. Both the incidence and mortality were projected to further increase by approximately 20% from 2012 to 2027. CONCLUSION: The incidence and mortality of pancreatic cancer have been rapidly rising and presumably will continue to rise in Taiwan.
BACKGROUND: Accumulating data has revealed a rapidly rising incidence of pancreatic cancer in Western countries, but convincing evidence from the East remains sparse. We aimed to quantify how the incidence and mortality rates of pancreatic malignancy changed over time in Taiwan, and to develop future projection for the next decade. METHODS: This nationwide population-based study analyzed the Taiwan National Cancer Registry and the National Cause of Death Registry to calculate the annual incidence and mortality rates of pancreatic malignancy from 1999 to 2012 in this country. The secular trend of the incidence was also examined by data from the National Health Insurance Research Database. RESULTS: A total of 21,986 incident cases of pancreatic cancer and 20,720 related deaths occurred during the study period. The age-standardized incidence rate increased from 3.7 per 100,000 in 1999 to 5.0 per 100,000 in 2012, with a significant rising trend (P<0.01). The increase was nationwide, consistently across subgroups stratified by age, gender, geographic region, and urbanization. Data from the National Health Insurance Research Database corroborated the rise of incident pancreatic cancer. Mortality also increased with time, with the age-standardized rate rising from 3.5 per 100,000 in 1999 to 4.1 per 100,000 in 2012 (P<0.01). In accordance with the incidence, the mortality trend was consistent in all subgroups. Both the incidence and mortality were projected to further increase by approximately 20% from 2012 to 2027. CONCLUSION: The incidence and mortality of pancreatic cancer have been rapidly rising and presumably will continue to rise in Taiwan.
Authors: Mario Capasso; Marilisa Franceschi; Kryssia Isabel Rodriguez-Castro; Pellegrino Crafa; Ginevra Cambiè; Chiara Miraglia; Alberto Barchi; Antonio Nouvenne; Gioacchino Leandro; Tiziana Meschi; Gian Luigi De' Angelis; Francesco Di Mario Journal: Acta Biomed Date: 2018-12-17