Fu-Chun Zhou1, Yuan-Yuan Wang2, Wei Zheng3, Qinge Zhang1, Gabor S Ungvari4, Chee H Ng5, Juan Zhang6, Yu-Tao Xiang7. 1. Department of Psychiatry, Beijing Anding Hospital, Capital Medical University; Beijing Key Laboratory of Mental Disorders; Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing, China. 2. Faculty of Health Sciences, University of Macau, Avenida da Universidade, 3/F, Building E12, Taipa, Macau SAR, China. 3. The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China. 4. The University of Notre Dame Australia / Marian Centre, Perth, Australia; School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia. 5. Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. 6. Faculty of Education, University of Macau, Macao SAR, China. 7. Faculty of Health Sciences, University of Macau, Avenida da Universidade, 3/F, Building E12, Taipa, Macau SAR, China. Electronic address: xyutly@gmail.com.
Abstract
BACKGROUND: Prospective memory (PM) can be impaired in patients with psychiatric disorders including depression. This meta-analysis systematically examined PM in patients with depression. METHODS: The meta-analysis was conducted according to the guidelines from Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Case-control studies on PM in patients with depression were included. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. RESULTS: Ten case-control studies (n = 596) comparing patients with depression (n = 299) with healthy controls (n = 297) were included in the analyses. Compared with healthy controls, patients with depression had significant impairment in event-based PM (EBPM) [8 trials, n = 436; SMD: -0.87 (95%CI: -1.43, -0.31), P = 0.002; I2 = 87%]. Significance was observed after removing two outlier trials [SMD: -0.44 (95%CI: -0.69, -0.20), P = 0.0004; I2 = 23%] and also in 8 out of the 13 subgroup analyses. Similarly, time-based PM (TBPM) was significantly impaired in patients with depression [4 trials, n = 239; SMD: -0.89 (95%CI: -1.46, -0.31), P = 0.003; I2 = 78%] when compared with healthy controls. CONCLUSIONS: This meta-analysis showed that both TBPM and EBPM appeared to be impaired in patients with depression.
BACKGROUND: Prospective memory (PM) can be impaired in patients with psychiatric disorders including depression. This meta-analysis systematically examined PM in patients with depression. METHODS: The meta-analysis was conducted according to the guidelines from Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Case-control studies on PM in patients with depression were included. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. RESULTS: Ten case-control studies (n = 596) comparing patients with depression (n = 299) with healthy controls (n = 297) were included in the analyses. Compared with healthy controls, patients with depression had significant impairment in event-based PM (EBPM) [8 trials, n = 436; SMD: -0.87 (95%CI: -1.43, -0.31), P = 0.002; I2 = 87%]. Significance was observed after removing two outlier trials [SMD: -0.44 (95%CI: -0.69, -0.20), P = 0.0004; I2 = 23%] and also in 8 out of the 13 subgroup analyses. Similarly, time-based PM (TBPM) was significantly impaired in patients with depression [4 trials, n = 239; SMD: -0.89 (95%CI: -1.46, -0.31), P = 0.003; I2 = 78%] when compared with healthy controls. CONCLUSIONS: This meta-analysis showed that both TBPM and EBPM appeared to be impaired in patients with depression.
Authors: Min Dong; Li Lu; Ling Zhang; Yun-Shu Zhang; Chee H Ng; Gabor S Ungvari; Gang Li; Xiangfei Meng; Gang Wang; Yu-Tao Xiang Journal: Psychiatr Q Date: 2019-09