Melissa Schorr1, Linda E Carlson2,3, Harold Y Lau3,4, Lihong Zhong2, Barry D Bultz2,3, Amy Waller2, Shannon L Groff2, Desiree Hao5,6. 1. Department of Medical Oncology, Tom Baker Cancer Centre, 1331-29th Street N.W., Calgary, AB, T2N 4N2, Canada. 2. Department of Psychosocial Oncology, Tom Baker Cancer Centre, Holy Cross Site Phase 1, 2202 2nd St. SW, Calgary, AB, T2S 3C1, Canada. 3. Cumming School of Medicine, Department of Oncology, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB, T2N 4N1, Canada. 4. Department of Radiation Oncology, Tom Baker Cancer Centre, 1331-29th Street N.W., Calgary, AB, T2N 4N2, Canada. 5. Department of Medical Oncology, Tom Baker Cancer Centre, 1331-29th Street N.W., Calgary, AB, T2N 4N2, Canada. Desiree.Hao@albertahealthservices.ca. 6. Cumming School of Medicine, Department of Oncology, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB, T2N 4N1, Canada. Desiree.Hao@albertahealthservices.ca.
Abstract
BACKGROUND: Human papillomavirus (HPV)-related cancers have been associated with different demographic profiles and disease characteristics than HPV-unrelated cancers in head and neck patients, but distress and other symptoms have not been compared. The aim of this study was to assess whether distress levels, fatigue, pain, anxiety, depression, and common psychological and practical problems differ between head and neck cancer patients with HPV-related vs. HPV-unrelated carcinomas (using oropharyngeal carcinoma (OPC) and non-OPC cancers as surrogates for HPV status). METHODS: Distress, depression, anxiety, fatigue, pain, and common problems were examined in 56 OPC and 90 non-OPC patients at 4 timepoints during the first year following diagnosis. Two-level hierarchical linear modeling was used to examine effects. RESULTS: The HPV-related OPC group was more likely to be younger (p = 0.05), Caucasian (p = 0.001), non-smokers (p = 0.01), earn more (p = 0.04), and present with more advanced stage (p < 0.0001). At baseline, OPC patients reported only higher pain scores (p = 0.01) than non-OPC patients. Total problems decreased more in the OPC group (p = 0.08) than the non-OPC group from baseline to 12-month follow-up. In both groups, scores on distress, depression, psychosocial problems, and practical problems decreased similarly over time. CONCLUSIONS: Despite a difference in the clinico-demographic characteristics of HPV-related vs. HPV-unrelated patients, only baseline pain levels and total problems over time differed between the two groups.
BACKGROUND:Human papillomavirus (HPV)-related cancers have been associated with different demographic profiles and disease characteristics than HPV-unrelated cancers in head and neck patients, but distress and other symptoms have not been compared. The aim of this study was to assess whether distress levels, fatigue, pain, anxiety, depression, and common psychological and practical problems differ between head and neck cancerpatients with HPV-related vs. HPV-unrelated carcinomas (using oropharyngeal carcinoma (OPC) and non-OPC cancers as surrogates for HPV status). METHODS: Distress, depression, anxiety, fatigue, pain, and common problems were examined in 56 OPC and 90 non-OPC patients at 4 timepoints during the first year following diagnosis. Two-level hierarchical linear modeling was used to examine effects. RESULTS: The HPV-related OPC group was more likely to be younger (p = 0.05), Caucasian (p = 0.001), non-smokers (p = 0.01), earn more (p = 0.04), and present with more advanced stage (p < 0.0001). At baseline, OPC patients reported only higher pain scores (p = 0.01) than non-OPC patients. Total problems decreased more in the OPC group (p = 0.08) than the non-OPC group from baseline to 12-month follow-up. In both groups, scores on distress, depression, psychosocial problems, and practical problems decreased similarly over time. CONCLUSIONS: Despite a difference in the clinico-demographic characteristics of HPV-related vs. HPV-unrelated patients, only baseline pain levels and total problems over time differed between the two groups.
Entities:
Keywords:
Distress; Head and neck cancer; Health-related quality of life; Human papillomavirus; Oropharyngeal; Psychosocial oncology
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