Literature DB >> 28600399

Validation of PDE5 as a Chemoprevention Target.

Gary A Piazza1.   

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Year:  2017        PMID： 28600399      PMCID： PMC5521204          DOI： 10.1158/1940-6207.CAPR-17-0136

Source DB:  PubMed          Journal:  Cancer Prev Res (Phila)        ISSN： 1940-6215


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  12 in total

1.  Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.

Authors:  Heather N Tinsley; Bernard D Gary; Jose Thaiparambil; Nan Li; Wenyan Lu; Yonghe Li; Yulia Y Maxuitenko; Adam B Keeton; Gary A Piazza
Journal:  Cancer Prev Res (Phila)       Date:  2010-09-28

2.  Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

Authors:  G A Piazza; D S Alberts; L J Hixson; N S Paranka; H Li; T Finn; C Bogert; J M Guillen; K Brendel; P H Gross; G Sperl; J Ritchie; R W Burt; L Ellsworth; D J Ahnen; R Pamukcu
Journal:  Cancer Res       Date:  1997-07-15       Impact factor: 12.701

Review 3.  NSAIDs inhibit tumorigenesis, but how?

Authors:  Evrim Gurpinar; William E Grizzle; Gary A Piazza
Journal:  Clin Cancer Res       Date:  2013-12-05       Impact factor: 12.531

4.  A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.

Authors:  Jason D Whitt; Nan Li; Heather N Tinsley; Xi Chen; Wei Zhang; Yonghe Li; Bernard D Gary; Adam B Keeton; Yaguang Xi; Ashraf H Abadi; William E Grizzle; Gary A Piazza
Journal:  Cancer Prev Res (Phila)       Date:  2012-05-03

5.  Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

Authors:  W J Thompson; G A Piazza; H Li; L Liu; J Fetter; B Zhu; G Sperl; D Ahnen; R Pamukcu
Journal:  Cancer Res       Date:  2000-07-01       Impact factor: 12.701

6.  Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC.

Authors:  Shiyong Lin; Jing Wang; Lihui Wang; Jing Wen; Yandong Guo; Weiguang Qiao; Jieqiong Zhou; Guoliang Xu; Fachao Zhi
Journal:  Am J Cancer Res       Date:  2017-01-01       Impact factor: 6.166

7.  Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis.

Authors:  F M Giardiello; S R Hamilton; A J Krush; S Piantadosi; L M Hylind; P Celano; S V Booker; C R Robinson; G J Offerhaus
Journal:  N Engl J Med       Date:  1993-05-06       Impact factor: 91.245

8.  β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG.

Authors:  Kevin Lee; Ashley S Lindsey; Nan Li; Bernard Gary; Joel Andrews; Adam B Keeton; Gary A Piazza
Journal:  Oncotarget       Date:  2016-02-02

9.  Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.

Authors:  Nan Li; Xi Chen; Bing Zhu; Verónica Ramírez-Alcántara; Joshua C Canzoneri; Kevin Lee; Sara Sigler; Bernard Gary; Yonghe Li; Wei Zhang; Mary P Moyer; E Alan Salter; Andrzej Wierzbicki; Adam B Keeton; Gary A Piazza
Journal:  Oncotarget       Date:  2015-09-29

10.  Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Authors:  N Li; K Lee; Y Xi; B Zhu; B D Gary; V Ramírez-Alcántara; E Gurpinar; J C Canzoneri; A Fajardo; S Sigler; J T Piazza; X Chen; J Andrews; M Thomas; W Lu; Y Li; D J Laan; M P Moyer; S Russo; B T Eberhardt; L Yet; A B Keeton; W E Grizzle; G A Piazza
Journal:  Oncogene       Date:  2014-04-07       Impact factor: 9.867
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  4 in total

Review 1.  PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity.

Authors:  Gary A Piazza; Antonio Ward; Xi Chen; Yulia Maxuitenko; Alex Coley; Nada S Aboelella; Donald J Buchsbaum; Michael R Boyd; Adam B Keeton; Gang Zhou
Journal:  Drug Discov Today       Date:  2020-06-17       Impact factor: 7.851

Review 2.  Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities.

Authors:  Hari Prasad; John Kandam Kulathu Mathew; Sandhya S Visweswariah
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-29       Impact factor: 6.055

Review 3.  Phosphodiesterase type 5 and cancers: progress and challenges.

Authors:  Ines Barone; Cinzia Giordano; Daniela Bonofiglio; Sebastiano Andò; Stefania Catalano
Journal:  Oncotarget       Date:  2017-10-12

4.  Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.

Authors:  Bing Zhu; Ashley Lindsey; Nan Li; Kevin Lee; Veronica Ramirez-Alcantara; Joshua C Canzoneri; Alexandra Fajardo; Luciana Madeira da Silva; Meagan Thomas; John T Piazza; Larry Yet; Brian T Eberhardt; Evrim Gurpinar; Dennis Otali; William Grizzle; Jacob Valiyaveettil; Xi Chen; Adam B Keeton; Gary A Piazza
Journal:  Oncotarget       Date:  2017-08-27
  4 in total

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