Literature DB >> 28600191

Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges.

Rajendran J C Bose1, Rramaswamy Ravikumar2, Vengadeshprabu Karuppagounder3, Devasier Bennet4, Sabarinathan Rangasamy5, Rajarajan A Thandavarayan6.   

Abstract

With rapid advances in nanomedicine, lipid-polymer hybrid nanoparticles (LPHNPs) have emerged as promising nanocarriers for several biomedical applications, including therapeutics delivery and biomedical imaging. Significant research has been dedicated to biomimetic or targeting functionalization, as well as controlled and image-guided drug-release capabilities. Despite this research, the clinical translation of LPHNP-mediated therapeutics delivery has progressed incrementally. In this review, we discuss the recent advances in and challenges to the development and application of LPHNPs, present examples to demonstrate the advantages of LPHNPs in therapeutics delivery and imaging applications, and discuss the translational obstacles to LPHNP technology.
Copyright © 2017. Published by Elsevier Ltd.

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Year:  2017        PMID： 28600191     DOI： 10.1016/j.drudis.2017.05.015

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  6 in total

1.  Fabrication of TPGS-Stabilized Liposome-PLGA Hybrid Nanoparticle Via a New Modified Nanoprecipitation Approach: In Vitro and In Vivo Evaluation.

Authors:  Mengyuan Zhang; Jianhua He; Wenli Zhang; Jianping Liu
Journal:  Pharm Res       Date:  2018-08-30       Impact factor: 4.200

2.  Lipid-polymer hybrid nanoparticles for controlled delivery of hydrophilic and lipophilic doxorubicin for breast cancer therapy.

Authors:  Nayab Tahir; Asadullah Madni; Alexandra Correia; Mubashar Rehman; Vimalkumar Balasubramanian; Muhammad Muzamil Khan; Hélder A Santos
Journal:  Int J Nanomedicine       Date:  2019-07-05

3.  Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery.

Authors:  Rajendran J C Bose; Nagendran Tharmalingam; Yonghyun Choi; Thiagarajan Madheswaran; Ramasamy Paulmurugan; Jason R McCarthy; Soo-Hong Lee; Hansoo Park
Journal:  Int J Nanomedicine       Date:  2020-10-29

4.  An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect.

Authors:  Mohamed Hamdi; Hend Mohamed Abdel-Bar; Enas Elmowafy; Khuloud T Al-Jamal; Gehanne A S Awad
Journal:  PLoS One       Date:  2020-01-10       Impact factor: 3.240

Review 5.  Therapeutic lipid-coated hybrid nanoparticles against bacterial infections.

Authors:  Lai Jiang; Hiang Wee Lee; Say Chye Joachim Loo
Journal:  RSC Adv       Date:  2020-02-27       Impact factor: 4.036

Review 6.  Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer.

Authors:  Jana K Alwattar; Amina T Mneimneh; Kawthar K Abla; Mohammed M Mehanna; Ahmed N Allam
Journal:  Pharmaceutics       Date:  2021-03-08       Impact factor: 6.321
  6 in total

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