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Literature DB >> 28600153

Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor.

Brian J Siroky¹, Alexander J Towbin², Andrew T Trout², Hannah Schäfer³, Anna R Thamann⁴, Karen D Agricola⁵, Cynthia Tudor⁵, Jamie Capal⁵, Bradley P Dixon⁴, Darcy A Krueger⁵, David N Franz⁵.

Abstract

Renal cysts occur in approximately 50% of patients with tuberous sclerosis complex, but their clinical significance and response to treatment are unknown. Abdominal imaging of 15 patients with tuberous sclerosis complex-associated renal cystic disease who had received mammalian target of rapamycin inhibitor therapy for other tuberous sclerosis complex-related indications was evaluated. Reductions in cyst number, sum diameter, and volume were observed.

Entities: Chemical Disease Gene Species

Keywords: autosomal dominant polycystic kidney disease; case series; contiguous gene syndrome; subependymal giant cell astrocytoma; tuberous sclerosis complex

Mesh：

Substances：

Year: 2017 PMID： 28600153 DOI： 10.1016/j.jpeds.2017.05.015

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

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Cited

9 in total

1. mTOR Inhibitor Therapy for Tuberous Sclerosis Complex: Longitudinal Study of Muscle Mass Determined by Abdominal Cross-sectional Imaging with CT and MRI.

Authors: Caroline Raab; Leah A Gilligan; Andrew T Trout; Darcy A Krueger; David N Franz; Bin Zhang; Alexander J Towbin
Journal: Radiol Imaging Cancer Date: 2020-09-18

2. Defining the Magnetic Resonance Features of Renal Lesions and Their Response to Everolimus in a Transgenic Mouse Model of Tuberous Sclerosis Complex.

Authors: Shubhangi Agarwal; Emilie Decavel-Bueff; Yung-Hua Wang; Hecong Qin; Romelyn Delos Santos; Michael J Evans; Renuka Sriram
Journal: Front Oncol Date: 2022-06-23 Impact factor: 5.738

Review 3. Thoracoabdominal imaging of tuberous sclerosis.

Authors: Cara E Morin; Nicholas P Morin; David N Franz; Darcy A Krueger; Andrew T Trout; Alexander J Towbin
Journal: Pediatr Radiol Date: 2018-08-04

4. Tuberous sclerosis complex exhibits a new renal cystogenic mechanism.

Authors: John J Bissler; Fahad Zadjali; Dave Bridges; Aristotelis Astrinidis; Sharon Barone; Ying Yao; JeAnna R Redd; Brian J Siroky; Yanqing Wang; Joel T Finley; Michael E Rusiniak; Heinz Baumann; Kamyar Zahedi; Kenneth W Gross; Manoocher Soleimani
Journal: Physiol Rep Date: 2019-01

5. International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people.

Authors: Charlotte Gimpel; Carsten Bergmann; Detlef Bockenhauer; Luc Breysem; Melissa A Cadnapaphornchai; Metin Cetiner; Jan Dudley; Francesco Emma; Martin Konrad; Tess Harris; Peter C Harris; Jens König; Max C Liebau; Matko Marlais; Djalila Mekahli; Alison M Metcalfe; Jun Oh; Ronald D Perrone; Manish D Sinha; Andrea Titieni; Roser Torra; Stefanie Weber; Paul J D Winyard; Franz Schaefer
Journal: Nat Rev Nephrol Date: 2019-11 Impact factor: 28.314

Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor.

1. mTOR Inhibitor Therapy for Tuberous Sclerosis Complex: Longitudinal Study of Muscle Mass Determined by Abdominal Cross-sectional Imaging with CT and MRI.

2. Defining the Magnetic Resonance Features of Renal Lesions and Their Response to Everolimus in a Transgenic Mouse Model of Tuberous Sclerosis Complex.

Review 3. Thoracoabdominal imaging of tuberous sclerosis.

4. Tuberous sclerosis complex exhibits a new renal cystogenic mechanism.

5. International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people.

6. Tsc2 mutation induces renal tubular cell nonautonomous disease.

Review 7. Perfect match: mTOR inhibitors and tuberous sclerosis complex.

8. Prevalence of thoracoabdominal imaging findings in tuberous sclerosis complex.

Review 9. Renal tumors in tuberous sclerosis complex.