| Literature DB >> 28598842 |
Michiaki Nagai1, Keigo Dote1, Masaya Kato1, Shota Sasaki1, Noboru Oda1, Eisuke Kagawa1, Yoshinori Nakano1, Aya Yamane1, Tasuku Higashihara1, Shunsuke Miyauchi1, Akane Tsuchiya1.
Abstract
While hypertension has been shown to be a risk factor for vascular dementia, several studies have also demonstrated that hypertension also increases the risk of Alzheimer's disease (AD). Although the relationship between visit-to-visit blood pressure variability (VVV) and cognitive impairment, including AD, have been provided, the mechanisms remain poorly understood. This review paper focuses on the relationship of VVV with AD and summarizes the pathophysiology underlying that relationship, which appears to be mediated by arterial stiffness.Entities:
Keywords: Alzheimer’s disease; amyloid beta; cognitive impairment; hypertension; visit-to-visit blood pressure variability
Mesh：
Year: 2017 PMID： 28598842 DOI： 10.3233/JAD-161172
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472