Literature DB >> 28598777

No histologic evidence of foetal cardiotoxicity following exposure to maternal hydroxychloroquine.

Deborah Friedman1, Leif Lovig2, Marc Halushka3, Robert M Clancy4, Peter M Izmirly4, Jill P Buyon5.   

Abstract

It is currently recommended that hydroxychloroquine (HCQ) be maintained during pregnancy in patients with systemic lupus erythematosus. Recent data suggest that this Toll-like receptor inhibitor may also reduce the recurrence rate of anti-SSA/Ro associated congenital heart block (CHB). This case report describes a unique situation in which a CHB-afflicted, HCQ-exposed pregnancy was electively terminated. The heart did not reveal any characteristic features of cardiotoxicity, providing further evidence supporting the safety of foetal exposure to HCQ.

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Year:  2017        PMID： 28598777      PMCID： PMC5657477     

Source DB:  PubMed          Journal:  Clin Exp Rheumatol        ISSN： 0392-856X            Impact factor:   4.473


  14 in total

1.  Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus.

Authors:  Carolina Llanos; Deborah M Friedman; Amit Saxena; Peter M Izmirly; Chung-E Tseng; Renata Dische; Rosanna G Abellar; Marc Halushka; Robert M Clancy; Jill P Buyon
Journal:  Rheumatology (Oxford)       Date:  2012-02-03       Impact factor: 7.580

Review 2.  Chloroquine cardiomyopathy - a review of the literature.

Authors:  Ernst Tönnesmann; Reinhard Kandolf; Thorsten Lewalter
Journal:  Immunopharmacol Immunotoxicol       Date:  2013-05-01       Impact factor: 2.730

3.  Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine.

Authors:  Peter M Izmirly; Mimi Y Kim; Carolina Llanos; Phuong U Le; Marta M Guerra; Anca D Askanase; Jane E Salmon; Jill P Buyon
Journal:  Ann Rheum Dis       Date:  2010-05-06       Impact factor: 19.103

Review 4.  Cardiomyopathy related to antimalarial therapy with illustrative case report.

Authors:  Nathalie Costedoat-Chalumeau; Jean-Sebastien Hulot; Zahir Amoura; Annick Delcourt; Thierry Maisonobe; Richard Dorent; Nicolas Bonnet; Régis Sablé; Philippe Lechat; Bertrand Wechsler; Jean-Charles Piette
Journal:  Cardiology       Date:  2006-06-22       Impact factor: 1.869

5.  Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women.

Authors:  A Brucato; M Frassi; F Franceschini; R Cimaz; D Faden; M P Pisoni; M Muscarà; G Vignati; M Stramba-Badiale; L Catelli; A Lojacono; I Cavazzana; A Ghirardello; F Vescovi; P F Gambari; A Doria; P L Meroni; A Tincani
Journal:  Arthritis Rheum       Date:  2001-08

6.  Hydroxychloroquine in lupus pregnancy.

Authors:  Megan E B Clowse; Laurence Magder; Frank Witter; Michelle Petri
Journal:  Arthritis Rheum       Date:  2006-11

7.  Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.

Authors:  Robert M Clancy; David Alvarez; Elena Komissarova; Franck J Barrat; Jordan Swartz; Jill P Buyon
Journal:  J Immunol       Date:  2010-01-20       Impact factor: 5.422

8.  New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy--a report of 2 cases.

Authors:  T Rinda Soong; Lili A Barouch; Hunter C Champion; Frederick M Wigley; Marc K Halushka
Journal:  Hum Pathol       Date:  2007-12       Impact factor: 3.466

9.  Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy: key diagnostic features and literature review.

Authors:  Emer Joyce; Aurelie Fabre; Niall Mahon
Journal:  Eur Heart J Acute Cardiovasc Care       Date:  2013-03

10.  Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors.

Authors:  Carolina Llanos; Peter M Izmirly; Margaret Katholi; Robert M Clancy; Deborah M Friedman; Mimi Y Kim; Jill P Buyon
Journal:  Arthritis Rheum       Date:  2009-10
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  2 in total

Review 1.  Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology.

Authors:  Eva Schrezenmeier; Thomas Dörner
Journal:  Nat Rev Rheumatol       Date:  2020-02-07       Impact factor: 20.543

2.  Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.

Authors:  Peter Izmirly; Mimi Kim; Deborah M Friedman; Nathalie Costedoat-Chalumeau; Robert Clancy; Joshua A Copel; Colin K L Phoon; Bettina F Cuneo; Rebecca E Cohen; Kimberly Robins; Mala Masson; Benjamin J Wainwright; Noel Zahr; Amit Saxena; Jill P Buyon
Journal:  J Am Coll Cardiol       Date:  2020-07-21       Impact factor: 24.094
  2 in total

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