Literature DB >> 28598505

Paving the way for Bartter syndrome type 3 drug discovery: a hope from basic research.

Paola Imbrici1, Diana Conte1, Antonella Liantonio1.   

Abstract

Entities:  

Keywords:  Bartter syndrome; ClC-K chloride channel; channelopathy

Mesh：

Substances：

Year:  2017        PMID： 28598505      PMCID： PMC5556148          DOI： 10.1113/JP274645

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  6 in total

1.  Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.

Authors:  R Estévez; T Boettger; V Stein; R Birkenhäger; E Otto; F Hildebrandt; T J Jentsch
Journal:  Nature       Date:  2001-11-29       Impact factor: 49.962

2.  Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan.

Authors:  Paola Imbrici; Domenico Tricarico; Giuseppe Felice Mangiatordi; Orazio Nicolotti; Marcello Diego Lograno; Diana Conte; Antonella Liantonio
Journal:  Br J Pharmacol       Date:  2017-04-26       Impact factor: 8.739

3.  Functional severity of CLCNKB mutations correlates with phenotypes in patients with classic Bartter's syndrome.

Authors:  Chih-Jen Cheng; Yi-Fen Lo; Jen-Chi Chen; Chou-Long Huang; Shih-Hua Lin
Journal:  J Physiol       Date:  2017-06-27       Impact factor: 5.182

4.  Barttin modulates trafficking and function of ClC-K channels.

Authors:  Ute Scholl; Simon Hebeisen; Audrey G H Janssen; Gerhard Müller-Newen; Alexi Alekov; Christoph Fahlke
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-18       Impact factor: 11.205

5.  Structure of a CLC chloride ion channel by cryo-electron microscopy.

Authors:  Eunyong Park; Ernest B Campbell; Roderick MacKinnon
Journal:  Nature       Date:  2016-12-21       Impact factor: 49.962

6.  Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.

Authors:  Paola Imbrici; Antonella Liantonio; Antonella Gradogna; Michael Pusch; Diana Conte Camerino
Journal:  Biochim Biophys Acta       Date:  2014-05-24
  6 in total

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