| Literature DB >> 28597686 |
Fei-Xiang Li1, Hui Wang1, Cui-Juan Gai1, Hui-Qin Chen1, Wei Li1, Wen-Li Mei1, Hao-Fu Dai1.
Abstract
Three new flavanoids, (2R)-7,4'-dihydroxy-8-methylflavan (1), (2R)-7,4'-dihydroxy-6-methylflavan (2), and (3R)-7,3',4'-trihydroxyhomoisoflavan (3), together with seven known compounds (4-10), were isolated from artificially induced dragon's blood of Dracaena cambodiana, and their structures were determined based on HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 2 exhibited weak cytotoxicity against BEL-7402 cells line with the IC50 value of 39.2 μM. In addition, compound 3 showed significant acetylcholinesterase (AChE) inhibitory activity.Entities:
Keywords: AChE; Artificially induced dragon’s blood; Dracaena cambodiana; cytotoxicity; flavanoids
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Year: 2017 PMID： 28597686 DOI： 10.1080/10286020.2017.1322583
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569