Literature DB >> 28596582

Cell Sheets of Co-cultured Endothelial Progenitor Cells and Mesenchymal Stromal Cells Promote Osseointegration in Irradiated Rat Bone.

Huan Liu1, Wei Zhou1, Nan Ren1, Zhihong Feng1, Yan Dong1, Shizhu Bai1, Yang Jiao2, Zhongshan Wang1, Yimin Zhao3.   

Abstract

Irradiated bone has a greater risk of implant failure than nonirradiated bone. The purpose of this study was to investigate the influence of cell sheets composed of co-cultured bone marrow mesenchymal stromal cells (BMSCs) and endothelial progenitor cells (EPCs) on implant osseointegration in irradiated bone. Cell sheets (EPCs, BMSCs or co-cultured EPCs and BMSCs) were wrapped around titanium implants to make cell sheet-implant complexes. The co-cultured group showed the highest osteogenic differentiation potential in vitro, as indicated by the extracellular matrix mineralization and the expression of osteogenesis related genes at both mRNA and protein levels. The co-cultured cells promoted ectopic bone formation as indicated by micro-computed tomography (Micro-CT) and histological analysis. In the irradiated tibias of rats, implants of the co-cultured group showed enhanced osseointegration by Micro-CT evaluation and histological observation. Co-cultured EPCs and BMSCs also up-regulated the expression of osteogenesis related genes in bone fragments in close contact with implants. In conclusion, cell sheets of co-cultured EPCs and BMSCs could promote osseous healing around implants and are potentially useful to improve osseointegration process for patients after radiotherapy.

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Year:  2017        PMID： 28596582      PMCID： PMC5465198          DOI： 10.1038/s41598-017-03366-9

Source DB:  PubMed          Journal:  Sci Rep        ISSN： 2045-2322            Impact factor:   4.379


  47 in total

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Journal:  Bone       Date:  2008-05-10       Impact factor: 4.398

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4.  Influence of mesenchymal stem cells with endothelial progenitor cells in co-culture on osteogenesis and angiogenesis: an in vitro study.

Authors:  Qiong Li; Zuolin Wang
Journal:  Arch Med Res       Date:  2013-10-10       Impact factor: 2.235

5.  The performance of bone marrow mesenchymal stem cell--implant complexes prepared by cell sheet engineering techniques.

Authors:  Wei Zhou; Chun Han; Yingliang Song; Xingrong Yan; Dehua Li; Zhiguo Chai; Zhihong Feng; Yan Dong; Liwen Li; Xing Xie; Fulin Chen; Yimin Zhao
Journal:  Biomaterials       Date:  2010-02-04       Impact factor: 12.479

Review 6.  Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair.

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Journal:  Adv Drug Deliv Rev       Date:  2015-04-08       Impact factor: 15.470

7.  Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone.

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Journal:  Tissue Eng Part A       Date:  2014-11-17       Impact factor: 3.845

8.  Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis.

Authors:  David M Smadja; Ivan Bièche; Jean-Sébastien Silvestre; Stéphane Germain; Adeline Cornet; Ingrid Laurendeau; Jean-Paul Duong-Van-Huyen; Joseph Emmerich; Michel Vidaud; Martine Aiach; Pascale Gaussem
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-09-25       Impact factor: 8.311

9.  Mesenchymal stem cells and endothelial progenitor cells stimulate bone regeneration and mineral density.

Authors:  Hadar Zigdon-Giladi; Tova Bick; Dina Lewinson; Eli E Machtei
Journal:  J Periodontol       Date:  2013-10-23       Impact factor: 6.993

10.  Chitosan/siCkip-1 biofunctionalized titanium implant for improved osseointegration in the osteoporotic condition.

Authors:  Li Zhang; Kaimin Wu; Wen Song; Haiyan Xu; Ran An; Lingzhou Zhao; Bin Liu; Yumei Zhang
Journal:  Sci Rep       Date:  2015-06-04       Impact factor: 4.379
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  10 in total

Review 1.  Cellular Based Strategies for Microvascular Engineering.

Authors:  Srinivas V Koduru; Ashley N Leberfinger; Denis Pasic; Anoosha Forghani; Shane Lince; Daniel J Hayes; Ibrahim T Ozbolat; Dino J Ravnic
Journal:  Stem Cell Rev Rep       Date:  2019-04       Impact factor: 5.739

Review 2.  Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.

Authors:  Daniel Jan Toneatti; Ronny Roger Graf; John-Patrik Burkhard; Benoît Schaller
Journal:  Clin Oral Investig       Date:  2021-08-16       Impact factor: 3.606

3.  [Construction of three-dimensional dermoid tissue based on cell sheets technology in vitro].

Authors:  Hua Xiang; Rui Chen; Shan Wu; Dali Xi; Siqi Long; Yuan Shen; Zengjie Fan; Liling Ren
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2020-01-15

4.  Endothelial progenitor cells improve the therapeutic effect of mesenchymal stem cell sheets on irradiated bone defect repair in a rat model.

Authors:  Huan Liu; Yang Jiao; Wei Zhou; Shizhu Bai; Zhihong Feng; Yan Dong; Qian Liu; Xiaoke Feng; Yimin Zhao
Journal:  J Transl Med       Date:  2018-05-22       Impact factor: 5.531

5.  miR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats.

Authors:  Huan Liu; Yan Dong; Xiaoke Feng; Liya Li; Yang Jiao; Shizhu Bai; Zhihong Feng; Hao Yu; Xuejian Li; Yimin Zhao
Journal:  Stem Cell Res Ther       Date:  2019-06-18       Impact factor: 6.832

6.  VEGF/VEGF-R/RUNX2 Upregulation in Human Periodontal Ligament Stem Cells Seeded on Dual Acid Etched Titanium Disk.

Authors:  Francesca Diomede; Guya Diletta Marconi; Marcos F X B Cavalcanti; Jacopo Pizzicannella; Sante Donato Pierdomenico; Luigia Fonticoli; Adriano Piattelli; Oriana Trubiani
Journal:  Materials (Basel)       Date:  2020-02-05       Impact factor: 3.623

7.  Co-culture with Endothelial Progenitor Cells promotes the Osteogenesis of Bone Mesenchymal Stem Cells via the VEGF-YAP axis in high-glucose environments.

Authors:  Peilian Wu; Xia Zhang; Yun Hu; Dongrong Liu; Jinlin Song; Wenjie Xu; Hao Tan; Rui Lu; Leilei Zheng
Journal:  Int J Med Sci       Date:  2021-02-04       Impact factor: 3.642

Review 8.  Implant-bone-interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo.

Authors:  Theresia Stich; Francisca Alagboso; Tomáš Křenek; Tomáš Kovářík; Volker Alt; Denitsa Docheva
Journal:  Bioeng Transl Med       Date:  2021-07-12

9.  Curcumin-mediated bone marrow mesenchymal stem cell sheets create a favorable immune microenvironment for adult full-thickness cutaneous wound healing.

Authors:  Zhi Yang; Chengmin He; Jinyang He; Jing Chu; Hanping Liu; Xiaoyuan Deng
Journal:  Stem Cell Res Ther       Date:  2018-01-31       Impact factor: 6.832

10.  Five Days Granulocyte Colony-Stimulating Factor Treatment Increases Bone Formation and Reduces Gap Size of a Rat Segmental Bone Defect: A Pilot Study.

Authors:  Marietta Herrmann; Stephan Zeiter; Ursula Eberli; Maria Hildebrand; Karin Camenisch; Ursula Menzel; Mauro Alini; Sophie Verrier; Vincent A Stadelmann
Journal:  Front Bioeng Biotechnol       Date:  2018-02-12
  10 in total

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