Literature DB >> 2859609

Role of brain neurotransmitters on neurotensin-induced gastric cytoprotection.

D E Hernandez, D A Stanley, J A Melvin, A J Prange.   

Abstract

We have reported previously that intracisternal (IC) administration of neurotensin (NT) prevents stress-induced gastric ulcers in rats. This effect of NT appears to be mediated by the central nervous system because peripheral (IV) NT is totally ineffective. The present study sought to clarify the central mechanism of the cytoprotective effect of NT by utilizing pharmacological treatments which alter the function of brain neurotransmitter systems. Pretreatment with intracerebroventricular (ICV) administration of agonists and antagonists of acetylcholine (ACh), gamma-aminobutyric acid (GABA), and serotonin (5-HT) receptors or with an anti-opiate (naloxone) agent did not significantly alter NT-induced cytoprotection. However, pretreatment with ICV haloperidol, a dopamine (DA) receptor antagonist, totally blocked NT's cytoprotective effect. In addition, pretreatment with methylphenidate, a DA receptor agonist, produced cytoprotection similar to IC NT. These data indicate that NT-induced cytoprotection is not mediated by 5-HT, GABA, ACh (muscarinic) receptors, or endogenous opiate systems, but suggest interactions between brain DA systems and NT.

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Year:  1985        PMID： 2859609     DOI： 10.1016/0091-3057(85)90266-7

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  6 in total

Review 1.  The amygdala. Emotions and gut functions.

Authors:  P G Henke; A Ray; R M Sullivan
Journal:  Dig Dis Sci       Date:  1991-11       Impact factor: 3.199

2.  Effects of dopamine on gastric mucosal lesions induced by ethanol in rats. Possible involvement of antigastric motor activity mediated with alpha 2-adrenoceptors.

Authors:  K Takeuchi; H Nishiwaki; S Okabe
Journal:  Dig Dis Sci       Date:  1988-12       Impact factor: 3.199

3.  Projection of neurotensin-like immunoreactive neurons from the lateral parabrachial area to the central amygdaloid nucleus of the rat with reference to the coexistence with calcitonin gene-related peptide.

Authors:  M Yamano; C J Hillyard; S Girgis; P C Emson; I MacIntyre; M Tohyama
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

Review 4.  Dopamine in gastrointestinal disease.

Authors:  G B Glavin; S Szabo
Journal:  Dig Dis Sci       Date:  1990-09       Impact factor: 3.199

Review 5.  Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future.

Authors:  Predrag Sikiric; Ki-Baik Hahm; Alenka Boban Blagaic; Ante Tvrdeic; Katarina Horvat Pavlov; Andrea Petrovic; Antonio Kokot; Slaven Gojkovic; Ivan Krezic; Domagoj Drmic; Rudolf Rucman; Sven Seiwerth
Journal:  Gut Liver       Date:  2020-03-15       Impact factor: 4.519

6.  Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome.

Authors:  Predrag Sikiric; Anita Skrtic; Slaven Gojkovic; Ivan Krezic; Helena Zizek; Eva Lovric; Suncana Sikiric; Mario Knezevic; Sanja Strbe; Marija Milavic; Antonio Kokot; Alenka Boban Blagaic; Sven Seiwerth
Journal:  World J Gastroenterol       Date:  2022-01-07       Impact factor: 5.742
  6 in total

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