Literature DB >> 28595661

The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis - Corrigendum.

A Q I Alqaisi, A J Mbekeani, M Bassas Llorens, A P Elhammer, P W Denny.   

Abstract

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Year:  2017        PMID: 28595661      PMCID: PMC5964473          DOI: 10.1017/S0031182017000877

Source DB:  PubMed          Journal:  Parasitology        ISSN: 0031-1820            Impact factor:   3.234


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The authors apologise for errors which appear in the legend of Figure 2. Please find below the corrected legend. Fig. 2. ED50 of Aureobasidin A (AbA, A-D) or Compound 20 (Cpmd 20, E-H) – µg mL−1; (95% Confidence Interval) – against the Toxoplasma RH tachyzoite form in HFF cells. 6 days post addition of the compounds. In agreement with Sonda et al. (2005), both compounds were non-toxic to HHF cells under the conditions employed. A and E: no wash out post-compound addition; B and F: wash out 2 h post-compound addition; C and G: wash out 8 h post-compound addition; D and H: 2 h pre-treatment of isolated parasites pre-infection. Calculated using GraphPad Prism 7, log (inhibitor) vs normalized response – Variable slope. >10 µg mL−1 – ED50 could not be determined. Representative in triplicate dataset.
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1.  The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis.

Authors:  A Q I Alqaisi; A J Mbekeani; M Bassas Llorens; A P Elhammer; P W Denny
Journal:  Parasitology       Date:  2017-05-10       Impact factor: 3.234

  1 in total
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Review 1.  Advances in Antifungal Drug Development: An Up-To-Date Mini Review.

Authors:  Ghada Bouz; Martin Doležal
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-16
  1 in total

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