| Literature DB >> 28595526 |
Francesco Landi1, Riccardo Calvani1, Matteo Cesari2,3, Matteo Tosato1, Anna Maria Martone1, Elena Ortolani1, Giulia Savera1, Sara Salini1, Alex Sisto1, Anna Picca1, Emanuele Marzetti1.
Abstract
Sarcopenia, the progressive and generalized loss of skeletal muscle mass and strength/function associated with aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. As such, sarcopenia poses a huge socioeconomic burden in developed countries. The development and implementation of effective interventions against sarcopenia are therefore a public health priority. A preliminary, fundamental step in such a process entails the agreement of researchers, healthcare professionals and policymakers around a unique operational definition of sarcopenia. This will facilitate the framing of a clear clinical entity to be incorporated in standard practice, the understanding of the underlying pathophysiology, and the identification of biological targets for drug development. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: Exercise; frailty; gait speed; muscle mass; muscle strength; operational definition; physical performance; protein.
Mesh:
Year: 2018 PMID: 28595526 DOI: 10.2174/1389203718666170607113459
Source DB: PubMed Journal: Curr Protein Pept Sci ISSN: 1389-2037 Impact factor: 3.272