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Literature DB >> 28594259

Targeting CDK4/6 to oppose hypoxia-mediated therapeutic resistance.

Noel A Warfel¹.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2017 PMID： 28594259 PMCID： PMC5531619 DOI： 10.1080/15384101.2017.1337975

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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7 in total

1. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.

Authors: Nobuhito Goda; Heather E Ryan; Bahram Khadivi; Wayne McNulty; Robert C Rickert; Randall S Johnson
Journal: Mol Cell Biol Date: 2003-01 Impact factor: 4.272

2. The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.

Authors: Jun Zhang; Lanlan Zhou; Shuai Zhao; David T Dicker; Wafik S El-Deiry
Journal: Cell Cycle Date: 2017-05-09 Impact factor: 4.534

3. Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.

Authors: Patrick A Mayes; Nathan G Dolloff; Colin J Daniel; J Judy Liu; Lori S Hart; Kageaki Kuribayashi; Joshua E Allen; David I H Jee; Jay F Dorsey; Yingqiu Y Liu; David T Dicker; J Martin Brown; Emma E Furth; Peter S Klein; Rosalie C Sears; Wafik S El-Deiry
Journal: Cancer Res Date: 2011-06-06 Impact factor: 12.701

1 in total

Review 1. Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer.

Authors: Sara El-Sahli; Lisheng Wang
Journal: Int J Mol Sci Date: 2020-11-30 Impact factor: 5.923

1 in total

Targeting CDK4/6 to oppose hypoxia-mediated therapeutic resistance.

1. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.

2. The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.

3. Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.

4. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation.

Review 5. HIF-1 signaling in drug resistance to chemotherapy.

6. CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.

7. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.

Review 1. Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer.