PURPOSE: The purpose of this study was to describe the trends and patterns of antidepressant (AD) prescribing to children and adolescents in Canadian primary care before and after the black-box warning in 2004. METHODS: Prescription data from the Canadian Primary Care Sentinel Surveillance Network, a repository of primary care data on over 1 million patients, was used to analyze AD prescribing to children (8-11 y) and adolescents (12-18 y) between 2000 and 2014. Interrupted time series analyses were used to assess the impact of the 2004 black-box warning on the prescribing levels of ADs. RESULTS: The 2004 black-box warning had a significant and immediate effect on the prescribing of AD. However, this drop was not sustained, and 5 years after the advisory AD prescribing rates reversed direction and started to rise. Selective serotonin reuptake inhibitors dominated as the most common AD prescribed throughout the study period, increasing from 66% prior to the black-box warning to 83.12% after 2009. CONCLUSIONS: The black-box warning effectively reduced AD prescribing in primary care for approximately 5 years before a reversal back to a positive rate of prescribing. This rebounding could reflect an emerging consensus about the trade-off in risks and benefits.
PURPOSE: The purpose of this study was to describe the trends and patterns of antidepressant (AD) prescribing to children and adolescents in Canadian primary care before and after the black-box warning in 2004. METHODS: Prescription data from the Canadian Primary Care Sentinel Surveillance Network, a repository of primary care data on over 1 million patients, was used to analyze AD prescribing to children (8-11 y) and adolescents (12-18 y) between 2000 and 2014. Interrupted time series analyses were used to assess the impact of the 2004 black-box warning on the prescribing levels of ADs. RESULTS: The 2004 black-box warning had a significant and immediate effect on the prescribing of AD. However, this drop was not sustained, and 5 years after the advisory AD prescribing rates reversed direction and started to rise. Selective serotonin reuptake inhibitors dominated as the most common AD prescribed throughout the study period, increasing from 66% prior to the black-box warning to 83.12% after 2009. CONCLUSIONS: The black-box warning effectively reduced AD prescribing in primary care for approximately 5 years before a reversal back to a positive rate of prescribing. This rebounding could reflect an emerging consensus about the trade-off in risks and benefits.
Authors: Marilyn N Vera-Chang; Antony D St-Jacques; Rémi Gagné; Chris J Martyniuk; Carole L Yauk; Thomas W Moon; Vance L Trudeau Journal: Proc Natl Acad Sci U S A Date: 2018-12-10 Impact factor: 11.205
Authors: M Greiver; S Dahrouge; P O'Brien; D Manca; M T Lussier; J Wang; F Burge; M Grandy; A Singer; M Twohig; R Moineddin; S Kalia; B Aliarzadeh; N Ivers; S Garies; J P Turner; B Farrell Journal: Implement Sci Date: 2019-06-06 Impact factor: 7.327
Authors: Marilyn N Vera-Chang; Antony D St-Jacques; Chunyu Lu; Thomas W Moon; Vance L Trudeau Journal: Front Neurosci Date: 2019-09-19 Impact factor: 4.677
Authors: Jenny W Sun; Sonia Hernández-Díaz; Sebastien Haneuse; Florence T Bourgeois; Seanna M Vine; Mark Olfson; Brian T Bateman; Krista F Huybrechts Journal: JAMA Psychiatry Date: 2021-01-01 Impact factor: 21.596