Literature DB >> 28592183

Vaginal film for prevention of HIV: using visual and tactile evaluations among potential users to inform product design.

K M Guthrie1,2,3, L Rohan4,5, R K Rosen1,3, S E Vargas1,2, J G Shaw1, D Katz6, E M Kojic7, A S Ham8, D Friend9, K W Buckheit8, R W Buckheit8.   

Abstract

Topical prevention of HIV and other STIs is a global health priority. To provide options for users, developers have worked to design safe, effective and acceptable vaginal dissolving film formulations. We aimed to characterize user experiences of vaginal film size, texture and color, and their role in product-elicited sensory perceptions (i.e. perceptibility), acceptability and willingness to use. In the context of a user-centered product evaluation study, we elicited users' 'first impressions' of various vaginal film formulation designs via visual and tactile prototype inspection during a qualitative user evaluation interview. Twenty-four women evaluated prototypes. Participants considered size and texture to be important for easy insertion. Color was more important following dissolution than prior to insertion. When asked to combine and balance all properties to arrive at an ideal film, previously stated priorities for individual characteristics sometimes shifted, with the salience of some individual characteristics lessening when multiple characteristics were weighted in combination. While first impressions alone may not drive product uptake, users' willingness to initially try a product is likely impacted by such impressions. Developers should consider potential users' experiences and preferences in vaginal film design. This user-focused approach is useful for characterizing user sensory perceptions and experiences relevant to early design of prevention technologies.

Entities:  

Keywords:  HIV prevention; Vaginal film; initial acceptability; multipurpose prevention technologies; perceptibility; user-centered product design

Mesh:

Substances:

Year:  2017        PMID: 28592183      PMCID: PMC5740013          DOI: 10.1080/10837450.2017.1339085

Source DB:  PubMed          Journal:  Pharm Dev Technol        ISSN: 1083-7450            Impact factor:   3.133


  9 in total

Review 1.  Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets.

Authors:  Sanjay Garg; David Goldman; Markus Krumme; Lisa C Rohan; Stuart Smoot; David R Friend
Journal:  Antiviral Res       Date:  2010-12       Impact factor: 5.970

2.  Prioritizing multipurpose prevention technology development and investments using a target product profile.

Authors:  Joe Romano; Judy Manning; Anke Hemmerling; Elizabeth McGrory; Bethany Young Holt
Journal:  Antiviral Res       Date:  2013-11-01       Impact factor: 5.970

3.  Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties.

Authors:  Kathleen M Morrow; Joseph L Fava; Rochelle K Rosen; Sara Vargas; Julia G Shaw; E Milu Kojic; Patrick F Kiser; David R Friend; David F Katz
Journal:  AIDS Res Hum Retroviruses       Date:  2013-12-09       Impact factor: 2.205

Review 4.  Development of topical microbicides to prevent the sexual transmission of HIV.

Authors:  Robert W Buckheit; Karen M Watson; Kathleen M Morrow; Anthony S Ham
Journal:  Antiviral Res       Date:  2009-10-27       Impact factor: 5.970

5.  Vaginal film drug delivery of the pyrimidinedione IQP-0528 for the prevention of HIV infection.

Authors:  Anthony S Ham; Lisa Cencia Rohan; Ashlee Boczar; Lu Yang; Karen W Buckheit; Robert W Buckheit
Journal:  Pharm Res       Date:  2012-03-06       Impact factor: 4.200

6.  Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission.

Authors:  Wei Zhang; Minlu Hu; Yuan Shi; Tiantian Gong; Charlene S Dezzutti; Bernard Moncla; Stefan G Sarafianos; Michael A Parniak; Lisa C Rohan
Journal:  Pharm Res       Date:  2015-03-21       Impact factor: 4.200

7.  Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design.

Authors:  Kate Morrow Guthrie; Shira Dunsiger; Sara E Vargas; Joseph L Fava; Julia G Shaw; Rochelle K Rosen; Patrick F Kiser; E Milu Kojic; David R Friend; David F Katz
Journal:  AIDS Res Hum Retroviruses       Date:  2016-03-29       Impact factor: 2.205

8.  A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film.

Authors:  Katherine E Bunge; Charlene S Dezzutti; Lisa C Rohan; Craig W Hendrix; Mark A Marzinke; Nicola Richardson-Harman; Bernard J Moncla; Brid Devlin; Leslie A Meyn; Hans M L Spiegel; Sharon L Hillier
Journal:  J Acquir Immune Defic Syndr       Date:  2016-04-15       Impact factor: 3.731

9.  Increased Dapivirine tissue accumulation through vaginal film codelivery of dapivirine and Tenofovir.

Authors:  Ayman Akil; Brid Devlin; Marilyn Cost; Lisa Cencia Rohan
Journal:  Mol Pharm       Date:  2014-04-14       Impact factor: 4.939

  9 in total
  10 in total

1.  The Role of Volume in the Perceptibility of Topical Vaginal Formulations: User Sensory Perceptions and Experiences of Heterosexual Couples During Vaginal Sex.

Authors:  Kate M Guthrie; Joseph L Fava; Sara E Vargas; Rochelle K Rosen; Julia G Shaw; Erna M Kojic; Anthony S Ham; Lisa C Rohan; David Katz; Anacecilia Panameño; Christopher Colleran; David F Friend; Karen W Buckheit; Robert W Buckheit
Journal:  AIDS Res Hum Retroviruses       Date:  2020-11-03       Impact factor: 2.205

2.  User input in iterative design for prevention product development: leveraging interdisciplinary methods to optimize effectiveness.

Authors:  Kate M Guthrie; Rochelle K Rosen; Sara E Vargas; Melissa Guillen; Arielle L Steger; Melissa L Getz; Kelley A Smith; Jaime J Ramirez; Erna M Kojic
Journal:  Drug Deliv Transl Res       Date:  2017-10       Impact factor: 4.617

3.  Designing Dual Compartment HIV Prevention Products: Women's Sensory Perceptions and Experiences of Suppositories for Rectal and Vaginal Use.

Authors:  Kate M Guthrie; Rochelle K Rosen; Melissa Guillen; Jaime J Ramirez; Sara E Vargas; Joseph L Fava; Anthony S Ham; David F Katz; Susan Cu-Uvin; Sheila Tumilty; Kelley A Smith; Karen W Buckheit; Robert W Buckheit
Journal:  AIDS Res Hum Retroviruses       Date:  2021-10-18       Impact factor: 1.723

4.  Users' Preferred Characteristics of Vaginal Rings for HIV Prevention: A Qualitative Analysis of Two Phase I Trials.

Authors:  Imogen Hawley; Mei Song; Rachel Scheckter; Tara McClure; Jeanna Piper; Beatrice A Chen; Craig Hoesley; Albert Y Liu; Ariane van der Straten
Journal:  AIDS Res Hum Retroviruses       Date:  2022-02-11       Impact factor: 1.723

5.  Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda.

Authors:  Rebecca L Callahan; Aurélie Brunie; Amelia C L Mackenzie; Madeleine Wayack-Pambè; Georges Guiella; Simon P S Kibira; Fredrick Makumbi
Journal:  PLoS One       Date:  2019-05-28       Impact factor: 3.240

Review 6.  Human-Centered Design Lessons for Implementation Science: Improving the Implementation of a Patient-Centered Care Intervention.

Authors:  Laura K Beres; Sandra Simbeza; Charles B Holmes; Chanda Mwamba; Njekwa Mukamba; Anjali Sharma; Virginia Munamunungu; Monica Mwachande; Kombatende Sikombe; Carolyn Bolton Moore; Aaloke Mody; Aybüke Koyuncu; Katerina Christopoulos; Lazarus Jere; Jake Pry; Peter D Ehrenkranz; Ashwin Budden; Elvin Geng; Izukanji Sikazwe
Journal:  J Acquir Immune Defic Syndr       Date:  2019-12       Impact factor: 3.731

7.  The new contraceptive revolution: developing innovative products outside of industry†,‡.

Authors:  Rebecca L Callahan; Neha J Mehta; Kavita Nanda; Gregory S Kopf
Journal:  Biol Reprod       Date:  2020-08-04       Impact factor: 4.285

8.  "I felt like a TRIO champion": end-user perspectives on their role as co-designers of multi-purpose technologies.

Authors:  Kawango Agot; Alexandra Lutnick; Mary Kate Shapley-Quinn; Khatija Ahmed; Timothy Okello; Ariane van der Straten
Journal:  Gates Open Res       Date:  2020-10-26

9.  Biodegradable polymeric solid implants for ultra-long-acting delivery of single or multiple antiretroviral drugs.

Authors:  Panita Maturavongsadit; Roopali Shrivastava; Craig Sykes; Mackenzie L Cottrell; Stephanie A Montgomery; Angela D M Kashuba; S Rahima Benhabbour
Journal:  Int J Pharm       Date:  2021-07-01       Impact factor: 6.510

10.  User evaluations offer promise for pod-intravaginal ring as a drug delivery platform: A mixed methods study of acceptability and use experiences.

Authors:  Kate M Guthrie; Rochelle K Rosen; Sara E Vargas; Melissa L Getz; Lauren Dawson; Melissa Guillen; Jaime J Ramirez; Marc M Baum; Kathleen L Vincent
Journal:  PLoS One       Date:  2018-05-14       Impact factor: 3.240

  10 in total

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