Literature DB >> 2859218

Indoxyl derivatives of drug metabolites.

J W Faigle, H Stierlin, H Mory, T Winkler, H P Kriemler.   

Abstract

Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2859218     DOI： 10.1007/bf01966155

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  Some observations concerning mammalian indoxyl metabolism and its relationship to the formation of urinary indigo pigments.

Authors:  J D Sapira; S Somani; A P Shapiro; E T Scheib; W Reihl
Journal:  Metabolism       Date:  1971-05       Impact factor: 8.694

2.  The effects of excessive bacterial proliferation on protein metabolism in rats with self-filling jejunal sacs.

Authors:  B Miller; R Mitchison; S Tabaqchali; G Neale
Journal:  Eur J Clin Invest       Date:  1971-11       Impact factor: 4.686

3.  Conversion of N-alkylaminobenzophenones to benzodiazepines in vivo.

Authors:  R A Lahti; M Gall
Journal:  J Med Chem       Date:  1976-08       Impact factor: 7.446

4.  The metabolism of [2-14C] indole in the rat.

Authors:  L J King; D V Parke; R T Williams
Journal:  Biochem J       Date:  1966-01       Impact factor: 3.857

5.  The biotransformation of 8-chloro-6-phenyl-4H-s-triazolo(4,3-a) (1,4) benzodiazepine (D-40TA), a new central depressant, in man, dog and rat.

Authors:  Y Kanai
Journal:  Xenobiotica       Date:  1974-07       Impact factor: 1.908

6.  Triazolam disposition.

Authors:  F S Eberts; Y Philopoulos; L M Reineke; R W Vliek
Journal:  Clin Pharmacol Ther       Date:  1981-01       Impact factor: 6.875
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.