Literature DB >> 2859206

Intramuscular bioavailability of chlorazepate as compared to diazepam.

A Bertler, S Lindgren, J O Magnusson, H Malmgren.   

Abstract

Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 mumol) DPC and 15 mg (52.0 mumol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.

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Year:  1985        PMID： 2859206     DOI： 10.1007/bf00609698

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  7 in total

1.  Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.

Authors:  L Hillestad; T Hansen; H Melsom; A Drivenes
Journal:  Clin Pharmacol Ther       Date:  1974-09       Impact factor: 6.875

2.  Benzodiazepines: clinical pharmacology and therapeutic use.

Authors:  C Bellantuono; V Reggi; G Tognoni; S Garattini
Journal:  Drugs       Date:  1980-03       Impact factor: 9.546

3.  Pharmacokinetics of clorazepate in pregnant and non-pregnant women.

Authors:  E Rey; P d'Athis; P Giraux; D de Lauture; J M Turquais; J Chavinie; G Olive
Journal:  Eur J Clin Pharmacol       Date:  1979-04-17       Impact factor: 2.953

4.  Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate.

Authors:  C Post; S Lindgren; A Bertler; H Malmgren
Journal:  Psychopharmacology (Berl)       Date:  1977-07-18       Impact factor: 4.530

5.  [Pharmacokinetic studies after oral and parenteral application of dipotassium chlorazepate (author's transl)].

Authors:  M Staak; A Moosmayer; K Besserer; K Speidel; A Kleinschmidt
Journal:  Arzneimittelforschung       Date:  1982

6.  Pharmacokinetics of chlorazepate after intravenous and intramuscular administration.

Authors:  A Bertler; S Lindgren; J O Magnusson; H Malmgren
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

7.  Pharmacokinetics of dipotassium chlorazepate in patients after repeated 50 mg oral doses.

Authors:  A Bertler; S Lindgren; H Malmgren
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530
  7 in total

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