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Literature DB >> 28591114

First deuterated drug approved.

Charles Schmidt.

Abstract

Mesh：

Substances：

Year: 2017 PMID： 28591114 DOI： 10.1038/nbt0617-493

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

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Cited

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36 in total

1. Heavy Heparin: A Stable Isotope-Enriched, Chemoenzymatically-Synthesized, Poly-Component Drug.

Authors: Brady F Cress; Ujjwal Bhaskar; Deepika Vaidyanathan; Asher Williams; Chao Cai; Xinyue Liu; Li Fu; Vandhana M-Chari; Fuming Zhang; Shaker A Mousa; Jonathan S Dordick; Mattheos A G Koffas; Robert J Linhardt
Journal: Angew Chem Int Ed Engl Date: 2019-04-01 Impact factor: 15.336

2. deutetrabenazine for the treatment of chorea associated with Huntington's disease.

Authors: Harshit Gupta; Wil Perkins; Cain Stark; Sathya Kikkeri; Juyeon Kakazu; Adam Kaye; Alan Kaye
Journal: Health Psychol Res Date: 2022-06-28

3. C(sp²)-H Activation with Bis(silylene)pyridine Cobalt(III) Complexes: Catalytic Hydrogen Isotope Exchange of Sterically-Hindered C-H Bonds.

Authors: Jose B Roque; Tyler P Pabst; Paul J Chirik
Journal: ACS Catal Date: 2022-07-11 Impact factor: 13.700

4. Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.

Authors: Xingui Liu; Zhengya Gao; Qiang Fu; Lin Song; Peiyi Zhang; Xuan Zhang; Howard Hendrickson; Peter A Crooks; Daohong Zhou; Guangrong Zheng
Journal: Bioorg Med Chem Date: 2020-04-08 Impact factor: 3.641

5. Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach.

Authors: Yueteng Zhang; Peng Ji; Yue Dong; Yongyi Wei; Wei Wang
Journal: ACS Catal Date: 2020-01-23 Impact factor: 13.084

6. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

Authors: Laura Friggeri; Tatiana Y Hargrove; Girish Rachakonda; Anna L Blobaum; Paxtyn Fisher; Gabriel Melo de Oliveira; Cristiane França da Silva; Maria de Nazaré C Soeiro; W David Nes; Craig W Lindsley; Fernando Villalta; F Peter Guengerich; Galina I Lepesheva
Journal: J Med Chem Date: 2018-11-30 Impact factor: 7.446

First deuterated drug approved.

1. Heavy Heparin: A Stable Isotope-Enriched, Chemoenzymatically-Synthesized, Poly-Component Drug.

2. deutetrabenazine for the treatment of chorea associated with Huntington's disease.

3. C(sp²)-H Activation with Bis(silylene)pyridine Cobalt(III) Complexes: Catalytic Hydrogen Isotope Exchange of Sterically-Hindered C-H Bonds.

4. Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.

5. Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach.

6. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

7. Production of deuterated biomass by cultivation of Lemna minor (duckweed) in D₂O.

8. Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides.

9. Formyl-selective deuteration of aldehydes with D₂O via synergistic organic and photoredox catalysis.

10. Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase.