Literature DB >> 2859083

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation.

R S Sloviter.   

Abstract

Perforant path stimulation for 24 h evoked hippocampal granule cell spikes and epileptiform discharges throughout the stimulation period. After stimulation, hippocampal neurons that receive granule cell output were irreversibly damaged and the stimulated hippocampus of each rat revealed a selective loss of Timm stain in the mossy fiber pathway. These results provide evidence in vivo for a role for synaptic zinc in neurotransmission and/or seizure mechanisms.

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Year:  1985        PMID： 2859083     DOI： 10.1016/0006-8993(85)90017-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  22 in total

1.  Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity.

Authors:  P Manzerra; M M Behrens; L M Canzoniero; X Q Wang; V Heidinger; T Ichinose; S P Yu; D W Choi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

2.  Measurement of intracellular free zinc in living cortical neurons: routes of entry.

Authors:  S L Sensi; L M Canzoniero; S P Yu; H S Ying; J Y Koh; G A Kerchner; D W Choi
Journal:  J Neurosci       Date:  1997-12-15       Impact factor: 6.167

3.  Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death.

Authors:  Hong Z Yin; Hwai-Lee Wang; Sung G Ji; Yuliya V Medvedeva; Guilian Tian; Afsheen K Bazrafkan; Niki Z Maki; Yama Akbari; John H Weiss
Journal:  J Neuropathol Exp Neurol       Date:  2019-07-01       Impact factor: 3.685

4.  Neurotoxicity of Clostridium perfringens epsilon-toxin for the rat hippocampus via the glutamatergic system.

Authors:  O Miyamoto; J Minami; T Toyoshima; T Nakamura; T Masada; S Nagao; T Negi; T Itano; A Okabe
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

5.  Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production.

Authors:  S L Sensi; H Z Yin; S G Carriedo; S S Rao; J H Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

6.  Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.

Authors:  Ranjana Poddar; Sathyanarayanan Rajagopal; C William Shuttleworth; Surojit Paul
Journal:  J Biol Chem       Date:  2015-11-16       Impact factor: 5.157

7.  Endogenous zinc in neurological diseases.

Authors:  Jae-Yong Koh
Journal:  J Clin Neurol       Date:  2005-10-20       Impact factor: 3.077

Review 8.  The essential toxin: impact of zinc on human health.

Authors:  Laura M Plum; Lothar Rink; Hajo Haase
Journal:  Int J Environ Res Public Health       Date:  2010-03-26       Impact factor: 3.390

9.  Abnormal targeting of developing hippocampal mossy fibers after epileptiform activities via L-type Ca2+ channel activation in vitro.

Authors:  Y Ikegaya
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

10.  Glutamate receptor changes in brain synaptic membranes from human alcoholics.

Authors:  E K Michaelis; W J Freed; N Galton; J Foye; M L Michaelis; I Phillips; J E Kleinman
Journal:  Neurochem Res       Date:  1990-11       Impact factor: 3.996
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