Literature DB >> 2859006

Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.

P Hofer, G Scollo-Lavizzari.   

Abstract

Thirteen patients with benzodiazepine overdosage received the specific benzodiazepine antagonist Ro 15-1788. Intravenous administration of 1.5 to 10 mg reversed the central nervous system depression induced by different benzodiazepine compounds within one to two minutes of injection. These case reports indicate that Ro 15-1788 may be an effective tool in the primary management of self-poisoning.

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Year:  1985        PMID： 2859006

Source DB:  PubMed          Journal:  Arch Intern Med        ISSN： 0003-9926


  11 in total

1.  Value of flumazenil in benzodiazepine self-poisoning.

Authors:  F Prischl; A Donner; G Grimm; R Smetana; K Hruby
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Jul-Aug

Review 2.  Principles of pharmacotherapy: I. Pharmacodynamics.

Authors:  T J Pallasch
Journal:  Anesth Prog       Date:  1988 May-Jun

Review 3.  A risk-benefit assessment of flumazenil in the management of benzodiazepine overdose.

Authors:  A A Weinbroum; R Flaishon; P Sorkine; O Szold; V Rudick
Journal:  Drug Saf       Date:  1997-09       Impact factor: 5.606

4.  Use of flumazenil in intoxicated patients with coma. A double-blind placebo-controlled study in ICU.

Authors:  R Ritz; M Zuber; S Elsasser; G Scollo-Lavizzari
Journal:  Intensive Care Med       Date:  1990       Impact factor: 17.440

Review 5.  The use of flumazenil in the management of acute drug poisoning--a review.

Authors:  A Weinbroum; P Halpern; E Geller
Journal:  Intensive Care Med       Date:  1991       Impact factor: 17.440

Review 6.  Benzodiazepine antagonists. An update of their role in the emergency care of overdose patients.

Authors:  P J Kulka; P M Lauven
Journal:  Drug Saf       Date:  1992 Sep-Oct       Impact factor: 5.606

Review 7.  Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment.

Authors:  P Gaudreault; J Guay; R L Thivierge; I Verdy
Journal:  Drug Saf       Date:  1991 Jul-Aug       Impact factor: 5.606

8.  Lack of effect of the benzodiazepine antagonist flumazenil (Ro 15-1788) on the performance of healthy subjects during experimentally induced ethanol intoxication.

Authors:  A Flückiger; D Hartmann; B Leishman; W H Ziegler
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

Review 9.  Flumazenil. A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use.

Authors:  R N Brogden; K L Goa
Journal:  Drugs       Date:  1988-04       Impact factor: 9.546

Review 10.  Flumazenil in benzodiazepine antagonism. Actions and clinical use in intoxications and anaesthesiology.

Authors:  R Amrein; B Leishman; C Bentzinger; G Roncari
Journal:  Med Toxicol Adverse Drug Exp       Date:  1987 Nov-Dec
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