Literature DB >> 28589989

Monitoring focal adhesion kinase phosphorylation dynamics in live cells.

Nur P Damayanti1, Kevin Buno2, Nagarajan Narayanan3, Sherry L Voytik Harbin2, Meng Deng3, Joseph M K Irudayaraj3.   

Abstract

Focal adhesion kinase (FAK) is a cytoplasmic non-receptor tyrosine kinase essential for a diverse set of cellular functions. Current methods for monitoring FAK activity in response to an extracellular stimulus lack spatiotemporal resolution and/or the ability to perform multiplex detection. Here we report on a novel approach to monitor the real-time kinase phosphorylation activity of FAK in live single cells by fluorescence lifetime imaging.

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Year:  2017        PMID： 28589989      PMCID： PMC5531600          DOI： 10.1039/c7an00471k

Source DB:  PubMed          Journal:  Analyst        ISSN： 0003-2654            Impact factor:   4.616


  23 in total

1.  Single-molecule tools elucidate H2A.Z nucleosome composition.

Authors:  Jiji Chen; Andrew Miller; Ann L Kirchmaier; Joseph M K Irudayaraj
Journal:  J Cell Sci       Date:  2012-03-05       Impact factor: 5.285

2.  Mechanisms of mechanical signaling in development and disease.

Authors:  Paul A Janmey; R Tyler Miller
Journal:  J Cell Sci       Date:  2011-01-01       Impact factor: 5.285

Review 3.  Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell.

Authors:  Shu Chien
Journal:  Am J Physiol Heart Circ Physiol       Date:  2006-11-10       Impact factor: 4.733

4.  Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane.

Authors:  Pierre-Alexandre Vidi; Jiji Chen; Joseph M K Irudayaraj; Val J Watts
Journal:  FEBS Lett       Date:  2008-11-12       Impact factor: 4.124

5.  Quantitative investigation of compartmentalized dynamics of ErbB2 targeting gold nanorods in live cells by single molecule spectroscopy.

Authors:  Jiji Chen; Joseph Irudayaraj
Journal:  ACS Nano       Date:  2009-12-22       Impact factor: 15.881

Review 6.  Mechanotransduction in development.

Authors:  Emmanuel Farge
Journal:  Curr Top Dev Biol       Date:  2011       Impact factor: 4.897

Review 7.  Focal adhesion kinase: in command and control of cell motility.

Authors:  Satyajit K Mitra; Daniel A Hanson; David D Schlaepfer
Journal:  Nat Rev Mol Cell Biol       Date:  2005-01       Impact factor: 94.444

8.  A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.

Authors:  Jianliang Zhang; Di-Hua He; Maria Zajac-Kaye; Steven N Hochwald
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 9.  Focal adhesion kinase and tumour angiogenesis.

Authors:  Tanguy Lechertier; Kairbaan Hodivala-Dilke
Journal:  J Pathol       Date:  2011-11-23       Impact factor: 7.996

10.  Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.

Authors:  Sachiko Murase
Journal:  Int J Mol Sci       Date:  2015-07-10       Impact factor: 5.923
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  3 in total

1.  Bioinspired glycosaminoglycan hydrogels via click chemistry for 3D dynamic cell encapsulation.

Authors:  Liangju Kuang; Nur P Damayanti; Chunhui Jiang; Xing Fei; Wenjie Liu; Naagarajan Narayanan; Joseph Irudayaraj; Osvaldo Campanella; Meng Deng
Journal:  J Appl Polym Sci       Date:  2018-11-01       Impact factor: 3.125

2.  Multiplexable fluorescence lifetime imaging (FLIM) probes for Abl and Src-family kinases.

Authors:  Sampreeti Jena; Nur P Damayanti; Jackie Tan; Erica D Pratt; Joseph M K Irudayaraj; Laurie L Parker
Journal:  Chem Commun (Camb)       Date:  2020-10-09       Impact factor: 6.222

3.  Modulation of Gene Silencing by Cdc7p via H4 K16 Acetylation and Phosphorylation of Chromatin Assembly Factor CAF-1 in Saccharomyces cerevisiae.

Authors:  Tiffany J Young; Yi Cui; Joseph Irudayaraj; Ann L Kirchmaier
Journal:  Genetics       Date:  2019-02-06       Impact factor: 4.562
  3 in total

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