Literature DB >> 28589497

Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders.

Khaled Saad1, Asmaa M Zahran2, Khalid I Elsayh3, Ahmed A Abdel-Rahman4, Abdulrahman A Al-Atram5, Almontaser Hussein3, Yasmin G El-Gendy6.   

Abstract

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.

Entities:  

Keywords:  Autism spectrum disorders; Children; Dendritic cells; Innate immunity

Mesh：

Substances：

Year:  2017        PMID： 28589497     DOI： 10.1007/s10803-017-3190-5

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  22 in total

Review 1.  Dendritic cell subsets in health and disease.

Authors:  Hideki Ueno; Eynav Klechevsky; Rimpei Morita; Caroline Aspord; Tinghua Cao; Toshimichi Matsui; Tiziana Di Pucchio; John Connolly; Joseph W Fay; Virginia Pascual; A Karolina Palucka; Jacques Banchereau
Journal:  Immunol Rev       Date:  2007-10       Impact factor: 12.988

Review 2.  Immune dysfunction and neuroinflammation in autism spectrum disorder.

Authors:  Geir Bjorklund; Khaled Saad; Salvatore Chirumbolo; Janet K Kern; David A Geier; Mark R Geier; Mauricio A Urbina
Journal:  Acta Neurobiol Exp (Wars)       Date:  2016       Impact factor: 1.579

Review 3.  [Research advances in immunological dysfunction in children with autism spectrum disorders].

Authors:  Tian-Tian Wang; Lin DU; Ling Shan; Fei-Yong Jia
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2014-12

Review 4.  Evidence supporting an altered immune response in ASD.

Authors:  Jennifer Mead; Paul Ashwood
Journal:  Immunol Lett       Date:  2014-11-20       Impact factor: 3.685

5.  Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder.

Authors:  Khaled Saad; Ahmed A Abdel-Rahman; Yasser M Elserogy; Abdulrahman A Al-Atram; Amira A El-Houfey; Hisham A-K Othman; Geir Bjørklund; Feiyong Jia; Mauricio A Urbina; Mohamed Gamil M Abo-Elela; Faisal-Alkhateeb Ahmad; Khaled A Abd El-Baseer; Ahmed E Ahmed; Ahmad M Abdel-Salam
Journal:  J Child Psychol Psychiatry       Date:  2016-11-21       Impact factor: 8.982

6.  Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors.

Authors:  Elizabeth Breece; Brian Paciotti; Christine Wu Nordahl; Sally Ozonoff; Judy A Van de Water; Sally J Rogers; David Amaral; Paul Ashwood
Journal:  Brain Behav Immun       Date:  2012-10-11       Impact factor: 7.217

7.  Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).

Authors:  Astrid G S van Halteren; Evelyne van Etten; Esther C de Jong; Roger Bouillon; Bart O Roep; Chantal Mathieu
Journal:  Diabetes       Date:  2002-07       Impact factor: 9.461

8.  1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.

Authors:  Gabriela B Ferreira; Conny A Gysemans; Jocelyne Demengeot; João Paulo M C M da Cunha; An-Sofie Vanherwegen; Lut Overbergh; Tom L Van Belle; Femke Pauwels; Annemieke Verstuyf; Hannelie Korf; Chantal Mathieu
Journal:  J Immunol       Date:  2014-03-24       Impact factor: 5.422

Review 9.  Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease.

Authors:  Darryl W Eyles; Thomas H J Burne; John J McGrath
Journal:  Front Neuroendocrinol       Date:  2012-07-11       Impact factor: 8.606

10.  A Comparison of the Autism Treatment Evaluation Checklist (ATEC) and the Childhood Autism Rating Scale (CARS) for the Quantitative Evaluation of Autism.

Authors:  David A Geier; Janet K Kern; Mark R Geier
Journal:  J Ment Health Res Intellect Disabil       Date:  2013-10
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  1 in total

1.  Serum Galanin in Children with Autism Spectrum Disorder.

Authors:  Khaled Saad; Ahmed A Abdel-Rahman; Abdulrahman A Al-Atram; Alam-Eldin M Abdallah; Amira Elhoufey; Eman M Nagiub Abdelsalam; Dalia A Nigm; Ola Elshora; Ahmad Roshdy Ahmad; Mohamed M El-Tellawy; Khaled Hashim Mahmoud
Journal:  Child Psychiatry Hum Dev       Date:  2021-02-03
  1 in total

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