Literature DB >> 2858939

Mitoses and binucleated cells in perinatal human hearts.

G Schmid, P Pfitzer.   

Abstract

Cells from hardened formalin-fixed human hearts were isolated with potash lye. In perinatal hearts mitoses and evidence of irregular chromosomal movement such as chromatin bridges and micronuclei were observed in small numbers during normal development. A quantitative analysis of binucleated cells shows 8.8 +/- 5.3% in the left and 11.7 +/- 4.0% in the right ventricular wall around the time of birth. The number increases during the first year of life to 56.8 +/- 17.4% in the left and 42.0 +/- 18.1% in the right heart. This development precedes normal polyploidisation of the human heart by years.

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Year:  1985        PMID： 2858939     DOI： 10.1007/bf02890115

Source DB:  PubMed          Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol        ISSN： 0340-6075


  17 in total

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Review 3.  Postnatal Cardiac Development and Regenerative Potential in Large Mammals.

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Review 4.  Significance of polyploidy in megakaryocytes and other cells in health and tumor disease.

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Review 8.  Regeneration of the heart.

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Review 9.  Thyroid hormone signaling and consequences for cardiac development.

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10.  A pig model of the preterm neonate: anthropometric and physiological characteristics.

Authors:  Yvonne A Eiby; Layne L Wright; Viskasari P Kalanjati; Stephanie M Miller; Stella T Bjorkman; Helen L Keates; Eugenie R Lumbers; Paul B Colditz; Barbara E Lingwood
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