Alfonso Iovieno1, Simonetta Piana2, Laura Chiesi3, Cristina Fodero4, Luigi Fontana5. 1. Department of Ophthalmology, Arcispedale Santa Maria Nuova - IRCCS, Viale Risorgimento, 80, 42121, Reggio Emilia, Italy. alfonsoiovieno@hotmail.com. 2. Pathology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy. 3. Institute of Ophthalmology, University of Modena, Modena, Italy. 4. Cervicovaginal Cytology Screening Center, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy. 5. Department of Ophthalmology, Arcispedale Santa Maria Nuova - IRCCS, Viale Risorgimento, 80, 42121, Reggio Emilia, Italy.
Abstract
PURPOSE: To describe a case of bilateral conjunctival and cervical human papillomavirus (HPV)-related squamous neoplasia. CASE DESCRIPTION: A healthy immunocompetent 55-year-old lady came to our attention for prosecution of care of a right recurrent conjunctival squamous cell carcinoma. Upon examination, she was found disease-free in the right eye but displayed a left conjunctival intraepithelial neoplasia (CIN grade I) and low-grade cervical squamous dysplasia. HPV infection with genotypes 16 (right eye), 11 and 39 (left eye) and 39 (uterine cervix) was also detected. CONCLUSION: Simultaneous uterine and conjunctival HPV-related squamous neoplasia can occur in immunocompetent individuals. Auto-inoculation and repeated exposure to HPV could explain coexistence of different genotypes.
PURPOSE: To describe a case of bilateral conjunctival and cervical human papillomavirus (HPV)-related squamous neoplasia. CASE DESCRIPTION: A healthy immunocompetent 55-year-old lady came to our attention for prosecution of care of a right recurrent conjunctival squamous cell carcinoma. Upon examination, she was found disease-free in the right eye but displayed a left conjunctival intraepithelial neoplasia (CIN grade I) and low-grade cervical squamous dysplasia. HPV infection with genotypes 16 (right eye), 11 and 39 (left eye) and 39 (uterine cervix) was also detected. CONCLUSION: Simultaneous uterine and conjunctival HPV-related squamous neoplasia can occur in immunocompetent individuals. Auto-inoculation and repeated exposure to HPV could explain coexistence of different genotypes.
Authors: M G Odrich; F A Jakobiec; W D Lancaster; K R Kenyon; L D Kelly; E W Kornmehl; R F Steinert; A S Grove; J W Shore; L Gregoire Journal: Ophthalmology Date: 1991-05 Impact factor: 12.079