| Literature DB >> 28587823 |
Yogesh B Surase1, Kirandeep Samby2, Sagar R Amale2, Ruchi Sood2, Kedar P Purnapatre2, Pawan K Pareek2, Biswajit Das2, Kamna Nanda2, Subodh Kumar3, Ashwani K Verma2.
Abstract
A non-diaryl quinoline scaffold 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one was identified by screening of diverse set of compounds against M. smegmatis ATP synthase. Herein, we disclose our efforts to develop the structure activity relationship against Mycobacterium tuberculosis (Mtb.H37Rv strain) around the identified hit 1. A scaffold hopping approach was used to identify compounds 14a, 14b and 24a with improved activity against MTb.H37Rv.Entities:
Keywords: ATP synthase; Anti-tubercular; Mtb; Non-darq; TMC207
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Year: 2017 PMID： 28587823 DOI： 10.1016/j.bmcl.2017.05.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823