Literature DB >> 28587732

For Certain, SIRT4 Activities!

Surinder Kumar1, David B Lombard2.   

Abstract

Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HMGylation; MGcylation; MGylation; SIRT4; Sirtuins

Mesh：

Substances：

Year:  2017        PMID： 28587732      PMCID： PMC5518788          DOI： 10.1016/j.tibs.2017.05.008

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  10 in total

1.  Acetyl-ed question in mitochondrial biology?

Authors:  David B Lombard; Banaja P Dash; Surinder Kumar
Journal:  EMBO J       Date:  2015-09-14       Impact factor: 11.598

2.  Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

Authors:  Martina Wirth; Samir Karaca; Dirk Wenzel; Linh Ho; Daniel Tishkoff; David B Lombard; Eric Verdin; Henning Urlaub; Monika Jedrusik-Bode; Wolfgang Fischle
Journal:  Mitochondrion       Date:  2013-02-21       Impact factor: 4.160

3.  The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

Authors:  Brian J North; Brett L Marshall; Margie T Borra; John M Denu; Eric Verdin
Journal:  Mol Cell       Date:  2003-02       Impact factor: 17.970

4.  A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Authors:  Gregory R Wagner; Dhaval P Bhatt; Thomas M O'Connell; J Will Thompson; Laura G Dubois; Donald S Backos; Hao Yang; Grant A Mitchell; Olga R Ilkayeva; Robert D Stevens; Paul A Grimsrud; Matthew D Hirschey
Journal:  Cell Metab       Date:  2017-04-04       Impact factor: 27.287

5.  SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Authors:  Kristin A Anderson; Frank K Huynh; Kelsey Fisher-Wellman; J Darren Stuart; Brett S Peterson; Jonathan D Douros; Gregory R Wagner; J Will Thompson; Andreas S Madsen; Michelle F Green; R Michael Sivley; Olga R Ilkayeva; Robert D Stevens; Donald S Backos; John A Capra; Christian A Olsen; Jonathan E Campbell; Deborah M Muoio; Paul A Grimsrud; Matthew D Hirschey
Journal:  Cell Metab       Date:  2017-04-04       Impact factor: 27.287

Review 6.  Mitochondrial sirtuins and their relationships with metabolic disease and cancer.

Authors:  Surinder Kumar; David B Lombard
Journal:  Antioxid Redox Signal       Date:  2015-02-10       Impact factor: 8.401

Review 7.  Mitochondrial Sirtuins and Molecular Mechanisms of Aging.

Authors:  Robert A H van de Ven; Daniel Santos; Marcia C Haigis
Journal:  Trends Mol Med       Date:  2017-03-10       Impact factor: 11.951

Review 8.  mTOR Signaling in Growth, Metabolism, and Disease.

Authors:  Robert A Saxton; David M Sabatini
Journal:  Cell       Date:  2017-03-09       Impact factor: 41.582

9.  Interaction of branched chain amino acids and keto acids upon pancreatic islet metabolism and insulin secretion.

Authors:  J C Hutton; A Sener; W J Malaisse
Journal:  J Biol Chem       Date:  1980-08-10       Impact factor: 5.157

10.  SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.

Authors:  Lei Li; Lan Shi; Shangda Yang; Ruorong Yan; Di Zhang; Jianguo Yang; Lin He; Wanjin Li; Xia Yi; Luyang Sun; Jing Liang; Zhongyi Cheng; Lei Shi; Yongfeng Shang; Wenhua Yu
Journal:  Nat Commun       Date:  2016-07-20       Impact factor: 14.919
  10 in total
  5 in total

Review 1.  Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions.

Authors:  Cora N Betsinger; Ileana M Cristea
Journal:  J Proteome Res       Date:  2019-04-08       Impact factor: 4.466

Review 2.  Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology.

Authors:  Surinder Kumar; David B Lombard
Journal:  Crit Rev Biochem Mol Biol       Date:  2018-04-11       Impact factor: 8.250

Review 3.  Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5.

Authors:  Francesco Fiorentino; Carola Castiello; Antonello Mai; Dante Rotili
Journal:  J Med Chem       Date:  2022-07-08       Impact factor: 8.039

Review 4.  Functions and Mechanisms of Lysine Glutarylation in Eukaryotes.

Authors:  Longxiang Xie; Yafei Xiao; Fucheng Meng; Yongqiang Li; Zhenyu Shi; Keli Qian
Journal:  Front Cell Dev Biol       Date:  2021-06-24

5.  Study of expression analysis of SIRT4 and the coordinate regulation of bovine adipocyte differentiation by SIRT4 and its transcription factors.

Authors:  Jieyun Hong; Shijun Li; Xiaoyu Wang; Chugang Mei; Linsen Zan
Journal:  Biosci Rep       Date:  2018-12-14       Impact factor: 3.840
  5 in total

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