Vincent Meuric1,2, Fabrice Lainé2,3, Emile Boyer1,2, Sandrine Le Gall-David2, Emmanuel Oger3, Denis Bourgeois4, Philippe Bouchard5,6, Edouard Bardou-Jacquet2,7, Valérie Turmel3, Martine Bonnaure-Mallet1,2, Yves Deugnier3,7. 1. CHU Rennes, Service d'Odontologie et de Chirurgie Buccale, Rennes, France. 2. EA 1254/CIMIAD (Control of Iron Metabolism and Iron-Associated Diseases), Université Rennes 1, UMR 1241, Rennes, France. 3. INSERM, CIC 1414, Rennes, France. 4. Université de Lyon 1, Lyon, France. 5. Department of Periodontology, Service of Odontology, Denis Diderot University, Rothschild Hospital, U.F.R. of Odontology, Paris, France. 6. EA 2496 Laboratory Orofacial Pathologies, Imagery and Biotherapies, Dental School and Life imaging Platform (PIV), University Paris Descartes Sorbonne Paris Cité, Montrouge, France. 7. CHU Rennes, Service des maladies du Foie, Rennes, France.
Abstract
AIM: To investigate the association between periodontal status and serum biomarkers in patients with HFE haemochromatosis. MATERIAL AND METHODS: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated. RESULTS: The study population consisted of 47 men and 37 women, routinely treated in the Unit of Hepatology, University Hospital, Rennes. All patients presented with periodontitis (mild: n = 1, moderate: n = 37 and severe: n = 46). There was a positive association between transferrin saturation >45% and the severity of periodontitis (adjusted odds ratio = 5.49, p = .002). CONCLUSION: Severe periodontitis is associated with the severity of iron burden in patients with HFE-related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients.
AIM: To investigate the association between periodontal status and serum biomarkers in patients with HFE haemochromatosis. MATERIAL AND METHODS: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated. RESULTS: The study population consisted of 47 men and 37 women, routinely treated in the Unit of Hepatology, University Hospital, Rennes. All patients presented with periodontitis (mild: n = 1, moderate: n = 37 and severe: n = 46). There was a positive association between transferrin saturation >45% and the severity of periodontitis (adjusted odds ratio = 5.49, p = .002). CONCLUSION: Severe periodontitis is associated with the severity of iron burden in patients with HFE-related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients.
Authors: Hani T Fadel; Mohammed A Zolaly; Manal O Alharbi; Lujain A Qarah; Maher S Alrehili; Abdulaziz D Alamri; Ahmed M Tarawah Journal: Int J Environ Res Public Health Date: 2020-12-16 Impact factor: 3.390