Literature DB >> 2858571

Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat.

F J Morales-Olivas, J Cortijo, J V Esplugues, E Rubio, J Esplugues.   

Abstract

The effect of verapamil and diltiazem on the contraction induced by agonists on the rat lower oesophageal sphincter in-vitro has been studied. Both calcium entry blockers inhibited the contractile response to acetylcholine, carbachol and KCl. The potency of the inhibitory action was diltiazem greater than verapamil. The results give substance to the use of calcium entry blockers in the treatment of oesophageal spasm.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2858571     DOI： 10.1111/j.2042-7158.1985.tb05044.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  4 in total

1.  Tetrodotoxin-sensitive and -insensitive relaxations in the rat oesophageal tunica muscularis mucosae.

Authors:  H I Akbarali; D Bieger; C R Triggle
Journal:  J Physiol       Date:  1986-12       Impact factor: 5.182

2.  Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects.

Authors:  E A Carapeti; M A Kamm; B K Evans; R K Phillips
Journal:  Gut       Date:  1999-11       Impact factor: 23.059

3.  Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure.

Authors:  Bikash Medhi; Ajay Prakash; Sujata Upadhyay; Deonis Xess; T D Yadav; L Kaman
Journal:  Indian J Surg       Date:  2011-10-18       Impact factor: 0.656

4.  Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo.

Authors:  R Brage; J Cortijo; J Esplugues; J V Esplugues; E Martí-Bonmatí; C Rodriguez
Journal:  Br J Pharmacol       Date:  1986-12       Impact factor: 8.739
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.