Literature DB >> 2858411

Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria.

K Jung, M Pergande.   

Abstract

In vitro exposure of isolated rat kidney mitochondria to cyclosporin A, a new immunosuppressive agent with serious nephrotoxic side-effects, leads to alterations of both succinate- and glutamate plus malate-supported respiration in a dose-related manner. ADP- and 2,4-dinitrophenol-stimulated respiration, respiratory control indices, and ADP/O ratios are decreased. The mitochondrial alterations are discussed as possible pathogenetic reasons of cyclosporin A nephrotoxicity.

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Year:  1985        PMID： 2858411     DOI： 10.1016/0014-5793(85)80977-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  Tacrolimus (FK506)-Associated Renal Pathology.

Authors:  Parmjeet S Randhawa; Thomas E Starzl; Anthony Jake Demetris
Journal:  Adv Anat Pathol       Date:  1997-07       Impact factor: 3.875

2.  Action of cyclosporine on mitochondrial calcium fluxes.

Authors:  N Fournier; G Ducet; A Crevat
Journal:  J Bioenerg Biomembr       Date:  1987-06       Impact factor: 2.945

3.  Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension.

Authors:  Akira Nishiyama; Hiroyuki Kobori; Toshiki Fukui; Guo-Xing Zhang; Li Yao; Matlubur Rahman; Hirofumi Hitomi; Hideyasu Kiyomoto; Takatomi Shokoji; Shoji Kimura; Masakazu Kohno; Youichi Abe
Journal:  Hypertension       Date:  2003-07-21       Impact factor: 10.190

4.  Protective effect of Epo on oxidative renal injury in rats with cyclosporine nephrotoxicity.

Authors:  Belde Kasap; Alper Soylu; Filiz Kuralay; Sülen Sarioglu; Müge Kiray; Kazim Tuğyan; Mehmet Türkmen; Salih Kavukcu
Journal:  Pediatr Nephrol       Date:  2008-07-11       Impact factor: 3.714

5.  Immunosuppressive and anti-proliferative effects of a macrotetrolide antibiotic, tetranactin.

Authors:  Y Tanouchi; H Shichi
Journal:  Immunology       Date:  1988-03       Impact factor: 7.397

Review 6.  Endocrine and metabolic abnormalities following kidney transplantation.

Authors:  W H Hörl; W Riegel; C Wanner; M Haag-Weber; P Schollmeyer; H Wieland; H Wilms
Journal:  Klin Wochenschr       Date:  1989-09-01

Review 7.  Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent.

Authors:  Derek J Hausenloy; E A Boston-Griffiths; D M Yellon
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

Review 8.  Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.

Authors:  John W Elrod; Jeffery D Molkentin
Journal:  Circ J       Date:  2013-03-29       Impact factor: 2.993

9.  Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats.

Authors:  Rosa Martha Perez Gutierrez
Journal:  Evid Based Complement Alternat Med       Date:  2012-09-12       Impact factor: 2.629

10.  Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats.

Authors:  Hasibur Rehman; Yasodha Krishnasamy; Khujista Haque; Ronald G Thurman; John J Lemasters; Rick G Schnellmann; Zhi Zhong
Journal:  PLoS One       Date:  2013-06-03       Impact factor: 3.240
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