Hannah Sinz1, Harald Renz1, Chrysanthi Skevaki2. 1. Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg GmbH Baldingerstr, Marburg, Germany. 2. Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg GmbH Baldingerstr, Marburg, Germany. Electronic address: chrysanthi.skevaki@uk-gm.de.
Abstract
OBJECTIVE: To provide an overview of studied cellular and noncellular blood-derived asthma biomarkers. DATA SOURCES: PubMed literature review. STUDY SELECTIONS: Articles discussing cellular and noncellular bloodborne asthma biomarkers. RESULTS: Discussed asthma biomarkers include peripheral blood cell counts of T cells, fibrocytes, or granulocytes, as well as levels of cytokines, periostin, IgE, and lipid mediators with or without stimulation. Moreover, this article summarizes the association of various blood biomarkers with the type of airway inflammation, presence of atopy, and dominance of specific T-cell subsets and associated pathways in asthma. Furthermore, biomarkers are here listed according to their proposed clinical use, such as diagnosis, disease phenotyping, classification of severity, assessment of disease control, and monitoring of and predicting treatment response. CONCLUSION: Further research on asthma biomarkers may improve asthma endotyping and ultimately lead to personalized treatment.
OBJECTIVE: To provide an overview of studied cellular and noncellular blood-derived asthma biomarkers. DATA SOURCES: PubMed literature review. STUDY SELECTIONS: Articles discussing cellular and noncellular bloodborne asthma biomarkers. RESULTS: Discussed asthma biomarkers include peripheral blood cell counts of T cells, fibrocytes, or granulocytes, as well as levels of cytokines, periostin, IgE, and lipid mediators with or without stimulation. Moreover, this article summarizes the association of various blood biomarkers with the type of airway inflammation, presence of atopy, and dominance of specific T-cell subsets and associated pathways in asthma. Furthermore, biomarkers are here listed according to their proposed clinical use, such as diagnosis, disease phenotyping, classification of severity, assessment of disease control, and monitoring of and predicting treatment response. CONCLUSION: Further research on asthma biomarkers may improve asthma endotyping and ultimately lead to personalized treatment.
Authors: Yining Jin; Haoran Gao; Rick Jorgensen; Jillian Salloum; Dan Ioan Jian; Perry K W Ng; Venugopal Gangur Journal: Int J Mol Sci Date: 2020-05-01 Impact factor: 5.923