Siying Liu1, Hangping Zheng1, Xiaoming Zhu1, Fei Mao1, Shuo Zhang1, Hongli Shi1, Yiming Li2, Bin Lu3. 1. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12# Middle Wulumuqi Road, Shanghai 200040, China. 2. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12# Middle Wulumuqi Road, Shanghai 200040, China. Electronic address: yimingli@fudan.edu.cn. 3. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 12# Middle Wulumuqi Road, Shanghai 200040, China. Electronic address: doctor_lubinfudan@126.com.
Abstract
OBJECTIVE: Diabetic peripheral neuropathy (DPN) had been demonstrated as a chronic inflammation state and one of the most common complications of type 2 diabetes mellitus (T2DM). Neutrophil-to-lymphocyte ratio (NLR) is a novel marker to reflect many kinds of chronic inflammation disease including diabetes. We aim to evaluate the association between NLR and DPN and to determine whether NLR could be a new indicator of DPN in type 2 diabetes patients. METHODS: We retrospect the consecutive medical files of T2DM patients. Nerve conduction velocity (NCV), vibration perception threshold (VPT) and the data for complete blood count were recorded. Patients were divided into tertiles based on admission NLR values. Clinical parameters were firstly compared among groups. Then, logistic regression and ROC analysis were performed. RESULTS: Percentages of DPN were 42.60%, 54.97% and 65.50%, in the low, middle and high tertile, respectively (n=72, 94 and 112, p<0.05). VPT values were 13.75±7.97, 15.01±9.60 and 16.78±10.92, respectively, (p<0.05). NCV in different nerves decreased with the increase of NLR (p<0.05). After adjusting potential related factors, NLR was still related to status of DPN in the logistic regression (r=1.743, p=0.001). Area under ROC was 0.619 (p<0.001). CONCLUSION: The present study showed that T2DM patients with higher NLR levels might be more likely to develop peripheral neuropathy complication. NLR levels grow with the increase of NCV and VPT results. As a predictor of DPN, NLR could be used in clinical practice to help doctors understand the level of DPN progression.
OBJECTIVE:Diabetic peripheral neuropathy (DPN) had been demonstrated as a chronic inflammation state and one of the most common complications of type 2 diabetes mellitus (T2DM). Neutrophil-to-lymphocyte ratio (NLR) is a novel marker to reflect many kinds of chronic inflammation disease including diabetes. We aim to evaluate the association between NLR and DPN and to determine whether NLR could be a new indicator of DPN in type 2 diabetespatients. METHODS: We retrospect the consecutive medical files of T2DM patients. Nerve conduction velocity (NCV), vibration perception threshold (VPT) and the data for complete blood count were recorded. Patients were divided into tertiles based on admission NLR values. Clinical parameters were firstly compared among groups. Then, logistic regression and ROC analysis were performed. RESULTS: Percentages of DPN were 42.60%, 54.97% and 65.50%, in the low, middle and high tertile, respectively (n=72, 94 and 112, p<0.05). VPT values were 13.75±7.97, 15.01±9.60 and 16.78±10.92, respectively, (p<0.05). NCV in different nerves decreased with the increase of NLR (p<0.05). After adjusting potential related factors, NLR was still related to status of DPN in the logistic regression (r=1.743, p=0.001). Area under ROC was 0.619 (p<0.001). CONCLUSION: The present study showed that T2DM patients with higher NLR levels might be more likely to develop peripheral neuropathy complication. NLR levels grow with the increase of NCV and VPT results. As a predictor of DPN, NLR could be used in clinical practice to help doctors understand the level of DPN progression.
Authors: Haifa Maalmi; Kristiaan Wouters; Christian Herder; Nicolaas C Schaper; Hans H C M Savelberg; Jeroen H P M van der Velde; Jos P H Reulen; Werner Mess; Casper G Schalkwijk; Coen D A Stehouwer; Michael Roden; Dan Ziegler Journal: BMJ Open Diabetes Res Care Date: 2021-01