Literature DB >> 28582544

Terbinafine resistance conferred by multiple copies of the salicylate 1-monooxygenase gene in Trichophyton rubrum.

Hemelin L Santos1, Elza A S Lang1, Fernando Segato1, Antonio Rossi1, Nilce M Martinez-Rossi1.   

Abstract

Resistance to antifungals is a leading concern in the treatment of human mycoses. We demonstrate that the salA gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte Trichophyton rubrum to terbinafine, one of the most effective antifungal drugs against dermatophytes. A strain with multiple copies of salA was constructed and exhibited elevated expression of salA and increased terbinafine resistance. This reflects a mechanism not yet reported in a pathogenic fungus.

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Year:  2018        PMID： 28582544     DOI： 10.1093/mmy/myx044

Source DB:  PubMed          Journal:  Med Mycol        ISSN： 1369-3786            Impact factor:   4.076


  8 in total

1.  The Growing Problem of Antifungal Resistance in Onychomycosis and Other Superficial Mycoses.

Authors:  Aditya K Gupta; Helen J Renaud; Emma M Quinlan; Neil H Shear; Vincent Piguet
Journal:  Am J Clin Dermatol       Date:  2020-12-22       Impact factor: 7.403

2.  Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection.

Authors:  Ditte M L Saunte; Rasmus K Hare; Karin M Jørgensen; René Jørgensen; Mette Deleuran; Claus O Zachariae; Simon F Thomsen; Lars Bjørnskov-Halkier; Kristian Kofoed; Maiken C Arendrup
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

3.  Phylogeny, Antifungal Susceptibility, and Point Mutations of SQLE Gene in Major Pathogenic Dermatophytes Isolated From Clinical Dermatophytosis.

Authors:  Nasrin Pashootan; Masoomeh Shams-Ghahfarokhi; Arash Chaichi Nusrati; Zahra Salehi; Mehdi Asmar; Mehdi Razzaghi-Abyaneh
Journal:  Front Cell Infect Microbiol       Date:  2022-03-18       Impact factor: 5.293

Review 4.  Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.

Authors:  Nilce M Martinez-Rossi; Tamires A Bitencourt; Nalu T A Peres; Elza A S Lang; Eriston V Gomes; Natalia R Quaresemin; Maíra P Martins; Lucia Lopes; Antonio Rossi
Journal:  Front Microbiol       Date:  2018-05-29       Impact factor: 5.640

5.  Congenital ichthyosis associated with Trichophyton rubrum tinea, imitating drug hypersensitivity reaction.

Authors:  Eszter Szlávicz; Csongor Németh; Éva Szepes; Csaba Gyömörei; Rolland Gyulai; Zsuzsanna Lengyel
Journal:  Med Mycol Case Rep       Date:  2020-05-29

6.  Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene.

Authors:  Simin Taghipour; Forough Shamsizadeh; Ivan M Pchelin; Ali Rezaei-Matehhkolaei; Ali Zarei Mahmoudabadi; Reza Valadan; Saham Ansari; Farzad Katiraee; Keyvan Pakshir; Kamiar Zomorodian; Mahdi Abastabar
Journal:  Infect Drug Resist       Date:  2020-03-13       Impact factor: 4.003

7.  Sophorolipid Biosurfactant Can Control Cutaneous Dermatophytosis Caused by Trichophyton mentagrophytes.

Authors:  Suparna Sen; Siddhartha Narayan Borah; Raghuram Kandimalla; Arijit Bora; Suresh Deka
Journal:  Front Microbiol       Date:  2020-03-12       Impact factor: 5.640

8.  Intrinsic resistance to terbinafine among human and animal isolates of Trichophyton mentagrophytes related to amino acid substitution in the squalene epoxidase.

Authors:  Dominik Łagowski; Sebastian Gnat; Aneta Nowakiewicz; Marcelina Osińska; Mariusz Dyląg
Journal:  Infection       Date:  2020-08-08       Impact factor: 3.553
  8 in total

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