David Herman1, Hyosun Han. 1. University of Southern Calfornia, Keck School of Medicine.
Abstract
PURPOSE OF REVIEW: Cytomegalovirus (CMV) is the most common opportunistic infection following solid-organ transplant and remains a cause of life-threatening disease and allograft rejection in liver transplant recipients. The purpose of this review is to highlight the current strategies in diagnosis and management of this disease in this vulnerable population. RECENT FINDINGS: Identification of high-risk individuals and aggressive treatment with antiviral agents, either via prophylaxis or by early initiation during active disease, has become the standard of care. Despite this, CMV continues to exert a significant effect, remaining a major cause of morbidity and mortality. SUMMARY: Given these findings, continuing efforts are underway to determine whether further therapy, vaccination, or alternative management strategies may improve outcomes in solid-organ transplant recipients. Until that time, however, aggressive monitoring of post-transplant patients for signs and symptoms of CMV infection is the best strategy to prevent solid-organ loss and death.
PURPOSE OF REVIEW: Cytomegalovirus (CMV) is the most common opportunistic infection following solid-organ transplant and remains a cause of life-threatening disease and allograft rejection in liver transplant recipients. The purpose of this review is to highlight the current strategies in diagnosis and management of this disease in this vulnerable population. RECENT FINDINGS: Identification of high-risk individuals and aggressive treatment with antiviral agents, either via prophylaxis or by early initiation during active disease, has become the standard of care. Despite this, CMV continues to exert a significant effect, remaining a major cause of morbidity and mortality. SUMMARY: Given these findings, continuing efforts are underway to determine whether further therapy, vaccination, or alternative management strategies may improve outcomes in solid-organ transplant recipients. Until that time, however, aggressive monitoring of post-transplant patients for signs and symptoms of CMV infection is the best strategy to prevent solid-organ loss and death.
Authors: Jéssica Vasques Raposo; Arthur Daniel Rocha Alves; Alexandre Dos Santos da Silva; Damião Carlos Dos Santos; Juliana Gil Melgaço; Otacílio C Moreira; Marcelo Alves Pinto; Vanessa Salete de Paula Journal: BMC Infect Dis Date: 2019-09-04 Impact factor: 3.090
Authors: Cornelius Engelmann; Martina Sterneck; Karl Heinz Weiss; Silke Templin; Steffen Zopf; Gerald Denk; Dennis Eurich; Johann Pratschke; Johannes Weiss; Felix Braun; Martin-Walter Welker; Tim Zimmermann; Petra Knipper; Dirk Nierhoff; Thomas Lorf; Elmar Jäckel; Hans-Michael Hau; Tung Yu Tsui; Aristoteles Perrakis; Hans-Jürgen Schlitt; Kerstin Herzer; Frank Tacke Journal: J Clin Med Date: 2020-07-23 Impact factor: 4.241