Contrast-Induced Nephropathy: Definitions, Epidemiology, and Implications.

Contrast-induced nephropathy, now termed contrast-induced acute kidney injury (CI-AKI), has been a long-recognized complication of administering intravascular iodinated contrast. This article reviews the newest literature on subclinical CI-AKI detected by novel biomarkers, and clinical CI-AKI recognized by an increase in serum creatinine and a reduction in urine output. Both components of CI-AKI are associated with adverse outcomes, including in-hospital complications, increased length of stay, need for renal replacement therapy, rehospitalization, permanent loss in renal filtration function, and death.