Heesun Moon1, Inyoung Choi1, Somi Kim1, Hyeonyoung Ko1, Jinyoung Shin2, Kayoung Lee3, Joohon Sung4, Yun-Mi Song1. 1. Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 2. Department of Family Medicine, Gangnam Severance Hospital, Yonsei University of College Department of Family Medicine, Seoul, Korea. 3. Department of Family Medicine, Busan Pack Hospital, Inje University, Busan, Korea. 4. Department of Epidemiology, School of Public Health and Institute of Health Environment, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVES: This study evaluated an association between testosterone, sex hormone-binding globulin (SHBG) and metabolic syndrome (MetS).We also evaluated the genetic and environmental influences on the association. DESIGN: Cross-sectional. SETTING: Community-based study. PARTICIPANTS: A total of 1098 Korean adult men including 139 monozygotic twin pairs. MAIN OUTCOME MEASURE: MetS was defined using the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP ATP III) and International Diabetes Federation (IDF) criteria. The associations between MetS and sex hormones were evaluated using linear mixed model and generalized estimating equation model. RESULTS: After considering covariates such as smoking, alcohol consumption and physical exercises as well as SHBG or testosterone, the risk of MetS defined by NCEP ATP III criteria decreased by 31%, 29%, and 48%, respectively, with 1-standard deviation increase in total testosterone (TT), free testosterone (cFT) and SHBG. Similar findings were revealed with IDF criteria. Metabolic component specific analysis showed that sex hormones were inversely associated with several components of MetS: TT with abdominal obesity, low high-density lipoprotein cholesterol (HDL-C) and high blood pressure; cFT with abdominal obesity and high blood pressure; SHBG with all components except high blood pressure. Cotwin control analysis found an inverse correlation between within-pair differences in testosterone and SHBG levels and within-pair differences in waist circumference only. CONCLUSION: Both testosterone and SHBG were inversely associated with MetS although the inverse associations with the sex hormones were not consistently found across individual metabolic components. Findings from cotwin analysis suggest a significant contribution of unshared unique environmental effect to the association between testosterone and SHBG and abdominal obesity.
OBJECTIVES: This study evaluated an association between testosterone, sex hormone-binding globulin (SHBG) and metabolic syndrome (MetS).We also evaluated the genetic and environmental influences on the association. DESIGN: Cross-sectional. SETTING: Community-based study. PARTICIPANTS: A total of 1098 Korean adult men including 139 monozygotic twin pairs. MAIN OUTCOME MEASURE: MetS was defined using the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP ATP III) and International Diabetes Federation (IDF) criteria. The associations between MetS and sex hormones were evaluated using linear mixed model and generalized estimating equation model. RESULTS: After considering covariates such as smoking, alcohol consumption and physical exercises as well as SHBG or testosterone, the risk of MetS defined by NCEP ATP III criteria decreased by 31%, 29%, and 48%, respectively, with 1-standard deviation increase in total testosterone (TT), free testosterone (cFT) and SHBG. Similar findings were revealed with IDF criteria. Metabolic component specific analysis showed that sex hormones were inversely associated with several components of MetS: TT with abdominal obesity, low high-density lipoprotein cholesterol (HDL-C) and high blood pressure; cFT with abdominal obesity and high blood pressure; SHBG with all components except high blood pressure. Cotwin control analysis found an inverse correlation between within-pair differences in testosterone and SHBG levels and within-pair differences in waist circumference only. CONCLUSION: Both testosterone and SHBG were inversely associated with MetS although the inverse associations with the sex hormones were not consistently found across individual metabolic components. Findings from cotwin analysis suggest a significant contribution of unshared unique environmental effect to the association between testosterone and SHBG and abdominal obesity.
Authors: Piotr Jarecki; Waldemar A Herman; Elżbieta Pawliczak; Katarzyna Lacka Journal: Diabetes Metab Syndr Obes Date: 2019-10-21 Impact factor: 3.168
Authors: Prachi Singh; Naima Covassin; Fatima H Sert-Kuniyoshi; Kara L Marlatt; Abel Romero-Corral; Diane E Davison; Ravinder J Singh; Michael D Jensen; Virend K Somers Journal: Physiol Rep Date: 2021-12