Michael W Chan1, Eugene Yu1,2, Eric Bartlett1,2, Brian O'Sullivan3,4, Jie Su5, John Waldron3,4, Jolie Ringash3, Scott V Bratman3, Yingming Amy Chen1, Jonathan Irish4, John Kim3, Patrick Gullane4, Ralph Gilbert4, Douglas Chepeha4, Bayardo Perez-Ordonez6, Ilan Weinreb6, Aaron Hansen7, Li Tong3, Wei Xu5, Shao Hui Huang3. 1. Department of Medical Imaging, Princess Margaret Cancer Centre / University of Toronto, Toronto, Ontario, Canada. 2. Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada. 3. Department of Radiation Oncology, Princess Margaret Cancer Centre / University of Toronto, Toronto, Ontario, Canada. 4. Department of Otolaryngology - Head and Neck Surgery, Princess Margaret Cancer Centre / University of Toronto, Toronto, Ontario, Canada. 5. Department of Biostatistics, Princess Margaret Cancer Centre / University of Toronto, Toronto, Ontario, Canada. 6. Department of Pathology, University Health Network, Toronto, Ontario, Canada. 7. Division of Medical Oncology, Princess Margaret Cancer Centre / University of Toronto, Toronto, Ontario, Canada.
Abstract
BACKGROUND: The purpose of this study was to compare the clinicoradiologic characteristics of human papillomavirus (HPV)-related (HPV-positive) and HPV-unrelated (HPV-negative) oropharyngeal carcinoma (OPC). METHODS: Primary tumor and lymph node features of HPV-positive and HPV-negative OPCs from 2008 to 2013 were compared on pretreatment CT/MRI. Intrarater/interrater concordance was assessed. Multivariable analyses identified factors associated with HPV-positivity to be used in nomogram construction. RESULTS: Compared to HPV-negative (n = 194), HPV-positive (n = 488) tumors were more exophytic (73% vs 63%; p = .02) with well-defined border (58% vs 47%; p = .033) and smaller axial dimensions; lymph node involvement predominated (89% vs 69%; p < .001) with cystic appearance (45% vs 32%; p = .009) but similar topography. Intrarater/interrater concordance varied (fair to excellent). Nomograms combining clinical (age, sex, smoking pack-years, subsite, T/N classification) and/or radiologic (nonnecrotic tumor and cystic lymph node) features were used to weigh the likelihood of HPV-driven tumors (area under the curve [AUC] = 0.84). CONCLUSION: HPV-positive OPC has different radiologic tumor (exophytic/well-defined border/smaller axial dimension) and lymph node (cystic) features but similar lymph node topography.
BACKGROUND: The purpose of this study was to compare the clinicoradiologic characteristics of human papillomavirus (HPV)-related (HPV-positive) and HPV-unrelated (HPV-negative) oropharyngeal carcinoma (OPC). METHODS:Primary tumor and lymph node features of HPV-positive and HPV-negative OPCs from 2008 to 2013 were compared on pretreatment CT/MRI. Intrarater/interrater concordance was assessed. Multivariable analyses identified factors associated with HPV-positivity to be used in nomogram construction. RESULTS: Compared to HPV-negative (n = 194), HPV-positive (n = 488) tumors were more exophytic (73% vs 63%; p = .02) with well-defined border (58% vs 47%; p = .033) and smaller axial dimensions; lymph node involvement predominated (89% vs 69%; p < .001) with cystic appearance (45% vs 32%; p = .009) but similar topography. Intrarater/interrater concordance varied (fair to excellent). Nomograms combining clinical (age, sex, smoking pack-years, subsite, T/N classification) and/or radiologic (nonnecrotic tumor and cystic lymph node) features were used to weigh the likelihood of HPV-driven tumors (area under the curve [AUC] = 0.84). CONCLUSION:HPV-positive OPC has different radiologic tumor (exophytic/well-defined border/smaller axial dimension) and lymph node (cystic) features but similar lymph node topography.
Authors: Travis C Salzillo; Nicolette Taku; Kareem A Wahid; Brigid A McDonald; Jarey Wang; Lisanne V van Dijk; Jillian M Rigert; Abdallah S R Mohamed; Jihong Wang; Stephen Y Lai; Clifton D Fuller Journal: Semin Radiat Oncol Date: 2021-10 Impact factor: 5.421
Authors: Gabriel Adrian; Henrik Carlsson; Elisabeth Kjellén; Johanna Sjövall; Björn Zackrisson; Per Nilsson; Maria Gebre-Medhin Journal: Radiat Oncol Date: 2022-06-14 Impact factor: 4.309
Authors: Ralph Th Leijenaar; Marta Bogowicz; Arthur Jochems; Frank Jp Hoebers; Frederik Wr Wesseling; Sophie H Huang; Biu Chan; John N Waldron; Brian O'Sullivan; Derek Rietveld; C Rene Leemans; Ruud H Brakenhoff; Oliver Riesterer; Stephanie Tanadini-Lang; Matthias Guckenberger; Kristian Ikenberg; Philippe Lambin Journal: Br J Radiol Date: 2018-03-22 Impact factor: 3.039